Currents in Pharmaceutical Research <p>Currents in Pharmacutical Research (CPR) is an International open access peer-reviewed journal that aims to publish high-quality research in the field of pharmaceutical sciences. The journal welcomes contributions from researchers worldwide and encourages interdisciplinary approaches that integrate pharmaceutical science with other related fields. The journal aims to be a valuable resource for the pharmaceutical industry, regulatory bodies, and healthcare professionals seeking to enhance their understanding of drug development, evaluation, and use.</p> en-US [email protected] (Prof. Dr. Ejaz Ullah Cheema) [email protected] (Ramna Zia) Tue, 05 Dec 2023 00:00:00 +0000 OJS 60 Phytochemical Screening and Anti-dandruff Activity of Fruit Husk Extracts of Cassia fistula Lin <p>Medicinal plants play a substantial role in treating various disorders. This study aims to evaluate the phytochemicals and anti-dandruff activity of a fruit husk of <em>Cassia fistula</em> Linn as a remedy for treating dandruff. Various extracts of fruit husk were extracted using sequential extraction methods, namely n-hexane, chloroform, and methanol. Primarily, the polyphenols and flavonoids of the various extracts were determined. The methanol extract contained the maximum number of polyphenols (48.97 ± 0.27), while the flavonoids were found in a large amount in the n-hexane extract (123.0 ± 0.82). Anti-dandruff activity was performed using a well-diffusion method against <em>Malassezia</em> species<em>. </em>At 1.0 g/mL concentration, n-hexane showed a zone of inhibition of 12.5 mm, while 18.50 mm and 20.50 mm at concentrations of 1.5 g/mL and 2.0 g/mL, respectively. At the concentration of 3000 mg/mL, the inhibition zone of 23.60 mm was observed. Extracts of <em>Cassia fistula linn</em> were effective for the treatment of dandruff. Therefore, <em>in vivo</em> studies are crucially required to explore the mechanism of action.</p> Mariam Busharat, Faiza Azhar, Ahsan Iqbal, Zainab Waheed, Muhammad Nauman Jamil Copyright (c) 2024 Currents in Pharmaceutical Research Tue, 05 Dec 2023 00:00:00 +0000 Medicine Related Problems (MRPs) in Adult Patients with Asthma and Chronic Obstructive Pulmonary Disease (COPD) <p>Asthma and Chronic Obstructive Pulmonary disease (COPD) have been classified as non-communicable diseases by the World Health Organization (WHO). These diseases contribute to the occurrence of around 4.2 million deaths globally. Medicine related problems (MRPs) refer to incidents associated with medicine therapy that interfere in the desired health outcomes. Patients with asthma and/or COPD are likely to encounter MRPs due to ineffective treatment, adverse drug reactions (ADRs), and/or medication errors (MEs). Therefore, the current study aimed to identify the prevalence, causes, and risk factors of MRPs among adult patients with asthma and/or COPD. A systematic literature review was conducted using 13 databases. These databases included PubMed, NELM, Embase, Scopus, ISI Web of Knowledge, ScienceDirect, PsycInfo, British Nursing Index, Global heath, International Pharmaceutical Abstracts, PsycExtra, and Cochrane Library. ‘Medicine related problems (MRPs)’ ‘adults’ ‘asthma’ ‘adverse drug reactions (ADRs)’ ‘drug related problems (DRPs)’ ‘adverse drug events (ADEs)’ ‘medication errors (MEs)’, and ‘Chronic Obstructive Pulmonary Disease’ ‘(COPD)’ were used as search items. Only quantitative studies, which investigated MRPs in adult patients with asthma and/or COPD, were included. The results of the review retrieved initially 1146338 titles that were considered. The analysis of the titles of these studies identified 55 relevant abstracts, of which, 15 were included in the review. The data extracted from these studies showed that the MRPs had a prevalence rate of 39.8%, ADRs 4.6%, while MEs had a prevalence rate of 66.9%. The comparison of these prevalence rates showed that MEs and MRPs had a higher prevalence than ADRs. Theophylline was reported to have the highest prevalence rate of MRPs which required special consideration to ensure its safe use by patients. The findings of the current study would potentially provide insights pertaining to the reduction of the high rate of MRPs.</p> Emma Packer, Sulaf Assi, Abdullah Al-Hamid Copyright (c) 2024 Currents in Pharmaceutical Research Tue, 05 Dec 2023 00:00:00 +0000 Identification of Counterfeit Tobacco using Attenuated Total Reflectance Fourier Transform Infrared, Raman, and Near-Infrared Spectroscopy <p>Counterfeit and illicit tobacco may contain potentially toxic organic impurities that result in adverse health effects for the consumer. Carcinogenic substances have been found in elevated concentrations in counterfeit tobacco. The current study explored swift and cost-effective methods, such as Fourier-transform infrared, Raman, and near-infrared spectroscopy to identify counterfeit tobacco products. Moreover, it also assessed the spectral quality based on range, number of peaks, maximum peak intensity, and signal-to-noise ratio. In spectral analysis, infrared exhibited superior quality over Raman and near-infrared with a higher signal-to-noise ratio. Near-infrared, although with a limited wavelength range, showed good quality. Raman, however, displayed poor spectral quality due to noise interference. Identification success varied with chemo-metric methods, with infrared correctly identifying four out of five counterfeit tobacco products and near-infrared identifying three out of five. Raman failed in identification, while infrared showed success with some mismatches using principal component analysis. Near-infrared and Raman successfully identified counterfeit tobacco, with near-infrared providing the most distinct separation. Quantification results varied across spectroscopy techniques and chemo-metric methods.</p> Phil Moorey, Fariha Imtiaz, Asra Shanzeh Shabbir, Nayab Pervez, Dhiya Al-Jumeily Copyright (c) 2024 Currents in Pharmaceutical Research Tue, 05 Dec 2023 00:00:00 +0000 Prevalence of Depression, Anxiety, and Stress among Breast Cancer Patients at a Tertiary Care Hospital in Faisalabad, Pakistan <p>The prevalence of depression in the patients of breast cancer is very common. The diagnosis of cancer produces stress, anxiety, and fear of pain and death in patients, all of which affect their physical and emotional wellbeing. These factors hinder the treatment of cancer because patients lose their will to live a happy and healthy life. The quality of life of people with psychiatric symptoms remains poor. Furthermore, there is a considerable risk that depressive symptoms in patients with breast cancer can lead to physical impairment and prolong mortality. The current descriptive and cross-sectional study was designed to determine depression, anxiety, and stress (DAS) levels in breast cancer patients&nbsp; at a tertiary care hospital in Faisalabad, Pakistan. The questionnaire included the socio-demographic, disease, and DAS related questions. A total of 138 women with breast cancer were included. The data was analyzed using SPSS software. The results showed that 38% of women had extremely severe depression, 68% were suffering from extremely severe anxiety, and 34% were facing extremely&nbsp;severe&nbsp;stress. The study showed that different factors were affecting the DAS scale, such as illiteracy (46.40%), occupation (labour 60.90%) and low income (76.80%) of husbands, sad reaction of families (60.10%), and the fear of chemotherapy&nbsp;(44.20%). Cancer patients need special attention and treatments to avoid emotional distress during their disease journey. This currebt study&nbsp; helps the healthcare professionals to provide psychological treatment to these patients.</p> Tanbeela Perveen, Rabbia Jawad, Iqra Afzal, Noreen Iftikhar, Bushra Aslam, Rabia Najeeb, Abida Nasreen Copyright (c) 2024 Currents in Pharmaceutical Research Tue, 05 Dec 2023 00:00:00 +0000 Evaluation of the Antidiabetic Activity of Asphodelus Tenuifolius in Normal and Alloxan-induced Diabetic Rats <p><em>Asphodelus tenuifolius</em> is traditionally used for the treatment of diabetes mellitus (DM). The current study aims to investigate the antidiabetic activity of <em>Asphodelus tenuifolius</em> in normal and alloxan-induced diabetic rats. Ethanolic and aqueous extracts of whole <em>Asphodelus tenuifolius</em> plant were prepared by using the maceration process. DM was induced by a single intraperitoneal injection of alloxan monohydrate (140 mg/kg b.w) in rats. Glibenclamide was used as the reference drug. In an acute study, ethanolic extract of <em>Asphodelus tenuifolius</em> (ATEE) and aqueous extract of <em>Asphodelus tenuifolius</em> (ATAqE) were administered in 200 and 400 mg/kg doses to normal and alloxan-induced diabetic rats. Both extracts (ATEE and ATAqE) significantly lowered the blood glucose level of both normal and diabetic treated rats in a concentration dependent fashion. However, ATEE produced prominent results at the dose of 400 mg/kg. In a fourteen-day study, ATEE considerably decreased the blood glucose level of alloxanized rats. The results were similar to the reference drug, that is, glibenclamide. In the prolonged study, the effects of ATEE on liver enzymes and hematological parameters of diabetic rats were also studied. Hb level and platelet count was increased in ATEE-treated diabetic rats as compared to diabetic control. However, it did not affect other hematological parameters. ATEE significantly decreased the ALP level as compared to diabetic control. Although, the test extract did not significantly alter the SGOT and SGPT levels. Further, the phytochemical testing of ATEE revealed the presence of alkaloids, flavonoids, tannins, and terpenoids. It was concluded that <em>Asphodeleus tenifolius</em> possesses antidiabetic activity. More comprehensive studies are needed in the future to explicate the mechanism of action and to characterize the phyto-components of this plant.</p> Sehrish Nadeem, Irfan Iqbal Khan, Muhammad Naveed Mushtaq, Muhammad Shafeeq Ur Rahman, Shaneel Kousar Copyright (c) 2024 Currents in Pharmaceutical Research Tue, 05 Dec 2023 00:00:00 +0000