https://journals.umt.edu.pk/index.php/CPR <p>Currents in Pharmaceutical Research (CPR) is an International open access peer-reviewed journal that aims to publish high-quality research in the field of pharmaceutical sciences. The journal welcomes contributions from researchers worldwide and encourages interdisciplinary approaches that integrate pharmaceutical science with other related fields. The journal aims to be a valuable resource for the pharmaceutical industry, regulatory bodies, and healthcare professionals seeking to enhance their understanding of drug development, evaluation, and use.</p> en-US <p>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution (CC-BY) 4.0 License</a>&nbsp;that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal</p> [email protected] (Prof. Dr. Ejaz Ullah Cheema) [email protected] (Ramna Zia) Sat, 28 Mar 2026 00:00:00 +0500 OJS 3.1.2.1 http://blogs.law.harvard.edu/tech/rss 60 https://journals.umt.edu.pk/index.php/CPR/article/view/7671 <p>Pathophysiology of Parkinson's disease (PD) is characterized by significant barriers to effective pharmacotherapy, primarily due to the limitation of the intact blood-brain barrier (BBB), the rapid metabolism of drug substances in the body, and the low bioavailability of most drugs. Traditional treatments, such as levodopa and dopamine agonists, provide temporary symptomatic relief and have limited half-lives and peripheral side effects, as well as strongly inconsistent plasma concentrations. Such drawbacks have spurred interest in nanocarrier-based drug delivery systems, which could offer targeted, prolonged neurotherapeutic delivery to the central nervous system. Polymeric micelles (PMs) are considered versatile and are mainly used due to their nanoscale size, biocompatibility, adaptable core-shell structure, and ability to entrap hydrophobic and hydrophilic molecules. The current study focused on the design, development, and evaluation of PM-based delivery to PD (especially rotigotine-loaded micelles and multifunctional structures that simultaneously provide antioxidants or neuroprotective factors). Furthermore, the study described essential formulation approaches, including ligand-functionalized surfaces to target the BBB, pH- or redox-controlled drug release, and intranasal delivery. The study discussed these methods in terms of improving drug localization and extending the treatment's effects in the brain. Although pre-clinical research has demonstrated high potential, the clinical implementation of PM-based systems remains limited by scalability challenges, regulatory ambiguity, and limited availability of long-term safety data. However, when such difficulties are overcome through standardized characterization, stringent pharmacokinetic analysis, and improved approval pathways, PMs could be a viable solution for a sustained, targeted, and possibly disease-modifying treatment in PD.</p> Mohammad Affan Mahmood, Muhammad Ali, Namirah Islam, Amima Naz, Aziza Ahmad, Shabana Naz Shah, Hajira Kanwal, Laiba Khan Copyright (c) 2026 Mohammad Affan Mahmood, Muhammad Ali, Namirah Islam, Amima Naz, Aziza Ahmad, Shabana Naz Shah, Hajira Kanwal, Laiba Khan https://creativecommons.org/licenses/by/4.0 https://journals.umt.edu.pk/index.php/CPR/article/view/7671 Sat, 28 Mar 2026 00:00:00 +0500