An Overview of Anticancer, Anti-inflammatory, Antioxidant, Antimicrobial, Cardioprotective, and Neuroprotective Effects of Rutin

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The current review focuses on the biological role and potential benefits of rutin, a natural flavonoid, in medical and pharmaceutical fields, especially for the treatment of different disorders in human beings. Rutin is present in various fruits and vegetables, such as tobacco, forsythia, buckwheat viola, apricots, cherries, grapefruit, plum, oranges, Japanese pagoda tree, eucalyptus macrorhyncha, St. John’s Wort, ginkgo, apples, and hydrangea as vitamin P. Its absorption is constrained by the gut flora, thus it is less bioavailable. However, in consolidation with other drugs, rutin shows enhanced properties such as anti-inflammatory, antioxidant, antimicrobial, cardioprotective, neuroprotective, and anticancer properties. Literature provides little data about its activity in cosmetics as antiaging, as well as its use in ulcerative colitis, autism, animal food, and pregnancy. Although several studies have revealed its activity against SARS-CoV-2. For this study, literature search was performed using various tools including books, Google Scholar, PubMed, and SpringerLink. A total of 370 research papers were studied. It was observed that 35% were about anticancer, 20% were about antioxidant, 15% were about anti-inflammatory activity of rutin, while 10% each were about antihypertensive, antimicrobial, and neuroprotective effects of rutin.