MicroRNAs: An Overview of their Discovery, Biogenesis, Computational Prediction, and Potential Clinical Applications

  • Iqra Kainat Institute of Biochemistry, Biotechnology and Bioinformatics, Islamia University of Bahawalpur, Bahawalpur, Pakistan
  • Sara Khan Department of Biochemistry and Biotechnology, Women University Multan, Pakistan
  • Anam Zahra Institute of Biochemistry, Biotechnology and Bioinformatics, Islamia University of Bahawalpur, Pakistan
  • Misbah Saleem Center of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan
DOI: https://doi.org/10.32350/cto.32.02
Keywords: biogenesis, biomarkers, cancer, diagnostic agents, developmental processes, miRNAs, therapeutic agents, tumors

Abstract

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The invention of next generation technologies which are aimed to resolve human health issues is gaining importance. Micro-RNAs (miRNAs) analysis is are an important discovery in the field of molecular biology. miRNAs are small endogenous RNAs which are involved in the regulation of post-transcriptional genes expression. They have been identified in different organisms, such as viruses, plants, human beings, and animals by using computational analysis tools. miRNAs are best predicted by next generation sequencing. They play a role as potential biomarkers in developmental processes. They are important therapeutic agents which play their role in diseases, such as cardiovascular, autoimmune, cancer, and neural degenerative diseases. The current study aimed to explore miRNAs and their clinical applications. For this purpose, miRNAs were analyzed as therapeutic agents and molecular biomarkers.

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Published
2023-08-25
How to Cite
Kainat, I., Khan, S., Zahra, A., & Saleem, M. (2023). MicroRNAs: An Overview of their Discovery, Biogenesis, Computational Prediction, and Potential Clinical Applications. Current Trends in OMICS, 3(2), 15-32. https://doi.org/10.32350/cto.32.02
Issue
Vol 3 No 2 (2023): Fall
Section
Articles

Copyright (c) 2023 Iqra Kainat, Sara Khan, Anam Zahra, Misbah Saleem

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