Decoding Breast Cancer Progression: Influence of miR-155-3p as Modulator of Molecular Signaling Pathways and Genetic Targets

Abstract

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Breast cancer is an eminent cause of fatality in women, worldwide. It is predominantly propelled by aberrant gene expression. A pivotal element in this mechanism is the disrupted regulation of microRNAs, particularly miR-155-3p. This investigation delves into the impact of miR-155-3p in breast cancer by employing advance methodologies, such as KEGG, DIANA, and Reactome Database, in order to unveil its genetic targets and molecular repercussions. It identifies six genes targeted and downregulated by miR-155-3p in breast cancer cells. This downregulation disrupts multiple vital biological pathways, including MAPK, AKT, STAT3, NFkB, and NOTCH signaling. These pathways play a crucial role in cellular processes, such as angiogenesis, apoptosis, DNA damage response, cell cycle control, and oncogene expression. Modifying these pathways by miR-155-3p underscores its substantial influence on the progression of breast cancer. The findings exemplify that the upregulation of miR-155-3p is a major contributing factor in the advancement of breast cancer. This upregulation initiates a series of molecular events that intensify the disease. Comprehending this mechanism is imperative for the development of targeted therapies. The implications of this research extend beyond the scientific community, presenting the potential for groundbreaking clinical applications. Furthermore, it establishes that miR-155-3p can be used as a diagnostic marker for breast cancer. This could significantly transform the landscape of breast cancer management, instilling hope both for improved outcomes and preventive strategies.