Exploring Niosomes: A Comprehensive Review of their Structure, Formulation, and Biomedical Applications
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Niosomes are a novel class of non-ionic surfactant vesicles. They have emerged as promising vesicles for the delivery of a diverse range of therapeutic agents. Niosomes are implied for the improvement of stability and solubility of molecules used in pharmaceutical components. The current study delved into the formulation methods, applications, and recent advancements in niosomal technology. They offer various benefits over other drug delivery systems due to their biocompatibility, biodegradability, and versatility. The first section of this study outlined the background, detailed structure, and characteristics of niosomes. Niosomes are quite distinct in their characteristics as they have the ability to encapsulate both hydrophilic and lipophilic drugs. The second section of the current study highlighted various methods employed for niosome preparation, such as film hydration, reverse-phase evaporation, and microfluidic techniques. By modifying the lipid composition and surfactants, specific physicochemical properties, such as size, lamellarity, and surface charge can be achieved.
The final section discussed applications of niosomes across pharmaceutical, cosmetic, and biotechnological fields. These include targeted drug delivery, gene delivery, cosmetic ingredient encapsulation, and vaccine adjuvant systems. Additionally, the recent advancements in niosome research have been discussed as well.
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Kaul S, Gulati N, Verma D, Mukherjee S, Nagaich U. Role of nanotechnology in cosmeceuticals: A review of recent advances. J Pharm (Cairo). 2018;2018:e3420204. https://doi.org/10.1155%2F2018 %2F3420204
Shaji J, Shah A. Niosomes: a novel drug delivery system. World J Pharm Res. 2015;4(06):853–876.
Karandikar S, Mirani A, Waybhase V, Patravale VB, Patankar S. Nanovaccines for oral delivery-formulation strategies and challenges. In: Andronescu E, Grumezescu AM, ed. Nanostructures for Oral Medicine. Elsevier; 2017:263–293. https://doi.org/10.1016/B978-0-323-47720-8.00011-0
SunilKumar MR, AdlinJinoNesalin J. Niosome as a novel drug delivery system-review. Int Res J Pharm Appl Sci. 2015;5(3):1–7.
Duarah S, Pujari K, Durai RD, Narayanan VHB. Nanotechnology-based cosmeceuticals: A review. Int J Appl Pharm. 2016;8(1):8–12. https://doi.org/10.22159/ijap.2016v8i1.10533
Jadhav C, Kate V, Payghan SA. Investigation of effect of non-ionic surfactant on preparation of griseofulvin non-aqueous nanoemulsion. J Nanostruct Chem. 2015;5(1):107–113. https://doi.org/10.1007/s40097-014-0141-y
Bhardwaj P, Tripathi P, Gupta R, Pandey S. Niosomes: a review on niosomal research in the last decade. J Drug Deliv Sci Technol. 2020;56:e101581. https://doi.org/10.1016/j.jddst.2020.101581
Dargah MS, Hadjizadeh A. Improvement of ascorbic acid delivery into human skin via hyaluronic acid-coated niosomes. J Microencapsul. 2022;39(6):552–562. https://doi.org/10.1080/02652048.2022.2135783
Yeo PL, Lim CL, Chye SM, Ling APK, Koh RY. Niosomes: a review of their structure, properties, methods of preparation, and medical applications. Asian Biomed. 2017;11(4):301–314.
Soliman GM. Nanoparticles as safe and effective delivery systems of antifungal agents: achievements and challenges. Int J Pharm. 2017;523(1):15–32. https://doi.org/10.1016/j.ijpharm.2017.03.019
Mariappan N. Recent trends in nanotechnology applications in surgical specialties and orthopedic surgery. Biomed Pharmacol J. 2019;12(3):1095–1127. https://dx.doi.org/10.13005/bpj/1739
Mehrarya M, Gharehchelou B, Haghighi Poodeh S, et al. Niosomal formulation for antibacterial applications. J Drug Target. 2022;30(5):476–493. https://doi.org/10.1080/1061186x.2022.2032094
Rosso A, Lollo G, Chevalier Y, et al. Development and structural characterization of a novel nanoemulsion for oral drug delivery. Colloids Surf A: Physicochem Eng Asp. 2020;593:e124614. https://doi.org/10.1016/j.colsurfa.2020.124614
Gharbavi M, Amani J, Kheiri-Manjili H, Danafar H, Sharafi A. Niosome: a promising nanocarrier for natural drug delivery through blood-brain barrier. Adv Pharmacol Sci. 2018:e6847971. https://doi.org/10.1155/2018/6847971
Debnath A, Kumar A. Structural and functional significance of niosome and proniosome in drug delivery system. Int J Pharm and Eng. 2015;3(3):621–637.
Rezaeizadeh M, Eskanlou A, Soltani H, Pardakhty A, Moshafi M-H, Hosseini-Nejad F. Preparation of stable clindamycin phosphate niosomes by combination of sorbitan esters and their ethoxylaed derivatives. J Pharm Innov. 2022;17:1189–1198. https://doi.org/10.1007/s12247-021-09594-x
Abdelkader H, Alani AW, Alany RG. Recent advances in non-ionic surfactant vesicles (niosomes): Self-assembly, fabrication, characterization, drug delivery applications and limitations. Drug Deliv. 2014;21(2):87–100. https://doi.org/10.3109/10717544.2013.838077
Kauslya A, Borawake PD, Shinde JV, Chavan RS. Niosomes: a novel carrier drug delivery system. J Drug Deliv Ther. 2021;11(1):162–170. https://doi.org/10.22270/jddt.v11i1.4479
Khatoon M, Shah KU, Din FU, et al. Proniosomes derived niosomes: Recent advancements in drug delivery and targeting. Drug Deliv. 2017;24(2):56–69. https://doi.org/10.1080/10717544.2017.1384520
Bseiso EA, Nasr M, Sammour O, Abd El Gawad NA. Recent advances in topical formulation carriers of antifungal agents. Indian J Dermatol Venereol Leprol. 2015;81(5):457–463.
Rahimpour Y, Kouhsoltani M, Hamishehkar H. Proniosomes in transdermal drug delivery. Curr Pharm Des. 2015;21(20):2883–2891.
Bourbour M, Khayam N, Noorbazargan H, et al. Evaluation of anti-cancer and anti-metastatic effects of folate-PEGylated niosomes for co-delivery of letrozole and ascorbic acid on breast cancer cells. Molecul Syst Des Eng. 2022;7(9):1102–1118.
Ascenso A, Raposo S, Batista C, et al. Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes. Int J Nanomed. 2015;10:5837–5851.
Garg V, Singh H, Bimbrawh S, et al. Ethosomes and transfersomes: principles, perspectives and practices. Curr Drug Deliv. 2017;14(5):613–633. https://doi.org/10.2174/1567201813666160520114436
Chavda VP. Niosome: a vesicular weapon for targeted and controlled drug delivery. Ind J Novel Drug Deliv. 2016;8(3):133–156.
Abdelbari MA, Elshafeey AH, Abdelbary AA, Mosallam S. Implementing nanovesicles for boosting the skin permeation of non-steroidal anti-inflammatory drugs. AAPS PharmSciTech. 2023;24(7):e195. https://doi.org/10.1208/s12249-023-02649-x
Muzzalupo R. Niosomes and proniosomes for enhanced skin delivery. In: Dragicevic N, Maibach H, eds. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Nanocarriers. Heidelberg: Springer; 2016:147–160.
Mokale V. Niosomes as an ideal drug delivery system. J NanoSci Res Rep. 2021;3(3):1–9.
Sah AK, Suresh PK. Medical management of glaucoma: focus on ophthalmologic drug delivery systems of timolol maleate. Artif Cells Nanomed Biotechnol. 2017;45(3):448–459. https://doi.org/10.3109/ 21691401.2016.1160917
Marianecci C, Di Marzio L, Rinaldi F, et al. Niosomes from 80s to present: the state of the art. Adv Colloid Interface Sci. 2014;205:187–206. https://doi.org/10.1016/j.cis.2013.11.018
Ge X, Wei M, He S, Yuan W-E. Advances of non-ionic surfactant vesicles (niosomes) and their application in drug delivery. Pharmaceutics. 2019;11(2):e55. https://doi.org/10.3390/pharmaceutics 11020055
Sezgin-Bayindir Z, Antep MN, Yuksel N. Development and characterization of mixed niosomes for oral delivery using candesartan cilexetil as a model poorly water-soluble drug. AAPS Pharmscit. 2015;16(1):108–117. https://doi.org/10.1208/s12249-014-0213-9
Yang Y, Liu L, Huang X, Tan X, Luo T, Li W. Temperature-induced vesicle to micelle transition in cationic/cationic mixed surfactant systems. Soft Matter. 2015;11(45):8848–8855. https://doi.org/10.1039/ C5SM01825K
Essa EA. Effect of formulation and processing variables on the particle size of sorbitan monopalmitate niosomes. Asian J Pharm. 2014;4(4):227–233.
Manca ML, Manconi M, Nacher A, et al. Development of novel diolein–niosomes for cutaneous delivery of tretinoin: Influence of formulation and in vitro assessment. Int J Pharm. 2014;477(1-2):176–186. https://doi.org/10.1016/j.ijpharm.2014.10.031
Kaur D, Kumar S. Niosomes: present scenario and future aspects. J Drug Deliv Ther. 2018;8(5):35–43. https://doi.org/10.22270/ jddt.v8i5.1886
Jin Y, Wen J, Garg S, et al. Development of a novel niosomal system for oral delivery of Ginkgo biloba extract. Int J Nanomed. 2013;8:421–430.
Dong C, Corsetti S, Passeri D, et al. Visualization and quantification of magnetic nanoparticles into vesicular systems by combined atomic and magnetic force microscopy. AIP Conf. Proc. 2015;1667(1):e020011. https://doi.org/10.1063/1.4922567
Pando D, Gutiérrez G, Coca J, Pazos C. Preparation and characterization of niosomes containing resveratrol. J Food Eng. 2013;117(2):227–234. https://doi.org/10.1016/j.jfoodeng.2013.02.020
Auda SH, Fathalla D, Fetih G, El-Badry M, Shakeel F. Niosomes as transdermal drug delivery system for celecoxib: in vitro and in vivo studies. Polym Bull. 2016;73(5):1229–1245. https://doi.org/10.1007/s00289-015-1544-8
Ceren ZE, Sezgin ZS, Yuksel N. Stability studies on piroxicam encapsulated niosomes. Curr Drug Deliv. 2015;12(2):192–199.
Ravalika V, Sailaja AK. Formulation and evaluation of etoricoxib niosomes by thin film hydration technique and ether injection method. Nano Biomed Eng. 2017;9(3):242–248. https://doi.org/10.5101/nbe. v9i3.p242-248
Moghassemi S, Hadjizadeh A. Nano-niosomes as nanoscale drug delivery systems: an illustrated review. J Controlled Release. 2014;185:22–36. https://doi.org/10.1016/j.jconrel.2014.04.015
Mahmoud K, Mohamed M, Amr I, Dina L. An overview on Niosomes: a drug nanocarrier. Drug Des Int Prop Int J. 2018;1(5):143–151. https://doi.org/10.32474/DDIPIJ.2018.01.000125
Yamaguchi S, Kimura Z, Misono T, et al. Preparation and properties of nonionic vesicles prepared with polyglycerol fatty acid esters using the supercritical carbon dioxide reverse phase evaporation method. J Oleo Sci. 2016:65(3)201–206. https://doi.org/10.5650/jos.ess15217
Yeo PL, Lim CL, Chye SM, Ling AK, Koh RY. Niosomes: a review of their structure, properties, methods of preparation, and medical applications. Asian Biomed. 2017;11(4):301–314. https://doi.org/10.1515/abm-2018-0002
Ojeda E, Agirre M, Villate-Beitia I, et al. Elaboration and physicochemical characterization of niosome-based nioplexes for gene delivery purposes. In: Candiani G, ed. Non-Viral Gene Delivery Vectors. New York, NY: Humana Press; 2016:63–75.
Bhavani G, Lakshmi P. Recent advances of non-ionic surfactant-based nano-vesicles (niosomes and proniosomes): a brief review of these in enhancing transdermal delivery of drug. Future J Pharm Sci. 2020;6(1):1–18.
Khan R, Irchhaiya R. Niosomes: a potential tool for novel drug delivery. J Pharm Investig. 2016;46(3):195–204. https://doi.org/10.1007/s40005-016-0249-9
Ag Seleci D, Seleci M, Walter J-G, Stahl F, Scheper T. Niosomes as nanoparticular drug carriers: fundamentals and recent applications. J Nanomater. 2016;2016:e7372306. https://doi.org/10.1155/2016/7372306
Kamboj S, Saini V, Bala S. Formulation and characterization of drug loaded nonionic surfactant vesicles (niosomes) for oral bioavailability enhancement. Sci World J. 2014;2014:e959741. https://doi.org/10.1155/2014/959741
Seyfoddin A, Sherwin T, V Patel D, et al. Ex vivo and in vivo evaluation of chitosan coated nanostructured lipid carriers for ocular delivery of acyclovir. Curr Drug Deliv. 2016;13(6):923–934.
Sharma D, Ali AAE, Aate JR. Niosomes as novel drug delivery system. Pharma Tutor. 2018;6(3):58–65.
Ray S, Bano N, Shukla T, Upmanyu N, Pandey S, Parkhe G. Noisomes: as novel vesicular drug delivery system. J Drug Deliv Ther. 2018;8:335–341. https://doi.org/10.22270/jddt.v8i6.2029
Makeshwar KB, Wasankar SR. Niosome: a novel drug delivery system. Asian J Pharm Res. 2013;3(1):16–20.
Ali ME, McConville JT, Lamprecht A. Pulmonary delivery of anti-inflammatory agents. Expert Opin Drug Deliv. 2015;12(6):929–945. https://doi.org/10.1517/17425247.2015.993968
Aparna A, Renuka P, Adukondalu D. Proniosomes: an emergent drug delivery system. Pharm Sci Monitor. 2014;5(3):47–54.
Farroq U, Bashir I, Jamshaid M, et al. Niosomes: a unique drug delivery tool. World J Pharm Pharm Sci. 2014;3:111–123.
Pawar S, Shevalkar G, Vavia P. Glucosamine-anchored doxorubicin-loaded targeted nano-niosomes: pharmacokinetic, toxicity and pharmacodynamic evaluation. J Drug Target. 2016;24(8):730–743. https://doi.org/10.3109/1061186X.2016.1154560
Rai AK, Alam G, Singh A, Verma N. Niosomes: an approach to current drug delivery-A Review. Int J Adv Pharm. 2017;6(2):41–48. https://dx.doi.org/10.7439/ijap.v6i2.3863
Sharma A, Kumar L, Kumar P, Prasad N, Rastogi V. Niosomes: a promising approach in drug delivery systems. J Drug Deliv Ther. 2019;9(4):635–642. https://doi.org/10.22270/jddt.v9i4.3064
Pandit J, Sultana Y, Kalam A. Newer technologies in oral vaccine delivery. Curr Drug Ther. 2014;9(3):173–187.
Pamornpathomkul B, Niyomtham N, Yingyongnarongkul B-E, et al. Cationic niosomes for enhanced skin immunization of plasmid DNA-encoding ovalbumin via hollow microneedles. AAPS PharmSciTech. 2018;19:481–488. https://doi.org/10.1208/s12249-017-0855-5
Afreen U, Fahelelbom KMS, Shah N, et al. Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy. J Exp Nanosci. 2022;17:467–495. https://doi.org/10.1080/17458080.2022.2094915
Muzzalupo R, Tavano L. Niosomal drug delivery for transdermal targeting: recent advances. Res Rep Transder Drug Deliv. 2015:23–33.
Bayindir ZS, Be AB, Yüksel N. Paclitaxel-loaded niosomes for intravenous administration: pharmacokinetics and tissue distribution in rats. Turk J Med Sci. 2015;45(6):1403–14012. https://doi.org/10.3906/sag-1408-129
Vadlamudi HC, Yalavarthi PR, Satyanarayana RP, Vandana K, Vulava J, Gutta TC. Formulation and pharmacodynamic evaluation of glibenclamide incorporated niosomal gel. Curr Drug Discov Technol. 2014;11(3):189–196. https://doi.org/10.2174/1570163811666140901153911
Rajera R, Nagpal K, Singh SK, Mishra DN. Niosomes: a controlled and novel drug delivery system. Biol Pharm Bull. 2011;34(7):945–953. https://doi.org/10.1248/bpb.34.945
Nasir A, Harikumar S, Amanpreet K. Niosomes: an excellent tool for drug delivery. Int J Res Pharm Chem. 2012;2(2):479–487.
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