Epidemiological Survey of the Prevalence of HCV and HBV among the Factory Workers in the Periphery of Lahore

  • Muhammad Khurram Pride Lab, Lahore, Punjab, Pakistan
  • Asma Irshad Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
  • Muhammad Alamgir Department of Pathology, Central Park Medical College, Lahore, Pakistan
  • Usman Ayub Awan Medical Laboratory Technology, The University of Haripur, Pakistan
  • Aamna Syed Pir Mehr Ali Shah Arid Agriculture University, Rawalpinidi, Pakistan
  • Haleema Sadia Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Balochistan, Pakistan
Keywords: Enzyme linked Immunosorbent Assay (ELISA), hepatitis C virus (HCV), hepatitis B virus (HBV), higher prevalence

Abstract

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Hepatitis C and hepatitis B are major health-related issues all over the globe. Both of these are iral infections that can be disseminated via sexual contact, by blood or the use of blood products, and through methods of intra-familial transmission. The collection of blood samples of factory workers was done aseptically at KBK Electronics. Overall, 272 samples of blood were taken from a variety of individuals. Economically accessible ELISA (Enzyme linked Immunosorbent Assay) was used to screen the individuals for Hepatitis B surface Antigen (HBsAg) and also for anti- HCV antibodies. Screening test was performed as directed by the instructions of the manufacturer. Name, gender and age group of each person was noted. Overall, 271 individuals were inspected to check the presence of HCV and HBV. The age of all the individuals ranged between 19 -50 years. The overall prevalence of both HCV and HBV was determined as 18.4% (50/271). As compare to HBV, HCV has a higher prevalence, that is, 16.17% (44/271). On the other hand, the prevalence of HBV was only 2.2% (6/271). The results of this study and previous literature highlight the pressing need to conduct epidemiological studies in smaller regions of the country.  It will help to specify the areas with higher HCV/HBV prevalence. Only then, various methods for treating and even precluding both of these infections can be implemented effectively.

Copyright (c) 2021 Muhammad Khurram, Asma Irshad, Muhammad Alamgir,Usman Ayub Awan, Haleema Sadia, Ammna Sayeed

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References

Jørgensen A, Bjørn-Mortensen K, Graff Jensen S, Sloth Andersen E, Ravn P. Prevalence of hepatitis B and C at a major tuberculosis centre in Denmark. Infect Dis. 2021;53(3):1-5. https://doi.org/10.1080/23744235.2020.1865562 DOI: https://doi.org/10.1080/23744235.2020.1865562

Pruß A, Chandrasekar A, Sánchez-Ibáñez J, Lucas-Samuel S, Kalus U, Rabenau HF. Algorithms for the testing of tissue donors for human immunodeficiency virus, hepatitis B virus, and hepatitis C virus. Transfusion Med Hemotherapy. 2021;48(1):12-21. https://doi.org/10.1159/000513179 DOI: https://doi.org/10.1159/000513179

Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol. 2014;61(1):S45-57. https://doi.org/10.1016/j.jhep.2014.07.027 DOI: https://doi.org/10.1016/j.jhep.2014.07.027

Lim AG, Qureshi H, Mahmood H, et al. Curbing the hepatitis C virus epidemic in Pakistan: the impact of scaling up treatment and prevention for achieving elimination. Int J Epidemiol. 2018;47(2):550-60. https://doi.org/10.1093/ije/dyx270 DOI: https://doi.org/10.1093/ije/dyx270

WHO. Global Health Sector Strategy on Viral Hepatitis 2016-2021. 2017. https://www.who.int/hepatitis/strategy2016-2021/ghss-hep/en/

European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67(2):370-98. https://doi.org/10.1016/j.jhep.2017.03.021 DOI: https://doi.org/10.1016/j.jhep.2017.03.021

Global Burden of Hepatitis C Working Group. Global burden of disease (GBD) for hepatitis C. The J Clin Pharmacol. 2004;44(1):20-29. https://doi.org/10.1177/0091270003258669 DOI: https://doi.org/10.1177/0091270003258669

Ali SA, Donahue RM, Qureshi H, Vermund SH. Hepatitis B and hepatitis C in Pakistan: prevalence and risk factors. Intl J Infect Dis. 2009;13(1):9-19. https://doi.org/10.1016/j.ijid.2008.06.019 DOI: https://doi.org/10.1016/j.ijid.2008.06.019

Waheed Y, Shafi T, Safi SZ, Qadri I. Hepatitis C virus in Pakistan: a systematic review of prevalence, genotypes and risk factors. World J Gastroenterol. 2009;15(45):5647-. https://doi.org/10.3748/wjg.15.5647 DOI: https://doi.org/10.3748/wjg.15.5647

Pakistan Medical Research Council. Federal Bureau of Statistics, Pakistan and Ministry of Health, Pakistan. (2018). National Survey on Prevalence of Hepatitis B & C in General Population of Pakistan (2007-2009). Pakistan Medical Research Council, Shahrah-e-Jamhuriat, Sector G-5/2, Islamabad.

Koulentaki M, Ergazaki M, Moschandrea J, et al. Prevalence of hepatitis B and C markers in high-risk hospitalised patients in Crete: a five-year observational study. BMC Public Health. 2001;1(1):1-8. https://doi.org/10.1186/1471-2458-1-17 DOI: https://doi.org/10.1186/1471-2458-1-17

Chaudhary IA, Khan SA. Samiullah: Should we do hepatitis B and C screening on each patient before surgery: Analysis of 142 cases. Pak J Med Sci. 2005;21(3):278-80.

Aslam M, Aslam J. Seroprevalence of the antibody to hepatitis C in select groups in the Punjab region of Pakistan. J Clin Gastroenterol. 2001;33(5):407-11. DOI: https://doi.org/10.1097/00004836-200111000-00013

Kowo MP, Yimagou EK, Ndam AW, et al. Prevalence of HBsAg and anti-HCV antibodies during a screening campaign in August 2019. Open J Gastroenterol Hepatol. 2021;4(1):45-50. DOI: https://doi.org/10.28933/ojgh-2021-01-0609

Plikaytis BD, Goldblatt D, Frasch CE, et al. An analytical model applied to a multicenter pneumococcal enzyme-linked immunosorbent assay study. J Clin Microbiol. 2000;38(6):2043-50. DOI: https://doi.org/10.1128/JCM.38.6.2043-2050.2000

Jafari S, Copes R, Baharlou S, Etminan M, Buxton J. Tattooing and the risk of transmission of hepatitis C: a systematic review and meta-analysis. Int J Infect Dis. 2010;14(11):e928-940. https://doi.org/10.1016/j.ijid.2010.03.019 DOI: https://doi.org/10.1016/j.ijid.2010.03.019

Ali M, Idrees M, Ali L, Hussain A, Rehman IU, Saleem S, Afzal S, Butt S. Hepatitis B virus in Pakistan: a systematic review of prevalence, risk factors, awareness status and genotypes. Virol J. 2011;8(1):1-9. DOI: https://doi.org/10.1186/1743-422X-8-102

World Health Organization. Global hepatitis report 2017. World Health Organization; 2017.

Umar M, tul Bushra H, Ahmad M, et al. Hepatitis C in Pakistan: A review of available data. Hepatitis Monthly. 2010;10(3):205-2014.

Idrees M, Khan S, Riazuddin S. Common genotypes of hepatitis B virus. J Coll Physicians Surg Pak. 2004;14(6):344-347.

Paraskevis D, Haida C, Tassopoulos N, Raptopoulou M, Tsantoulas D, Papachristou H, Sypsa V, Hatzakis A. Development and assessment of a novel real-time PCR assay for quantitation of HBV DNA. J Virolog Meth. 2002;103(2):201-12. https://doi.org/10.1016/S0166-0934(02)00033-2 DOI: https://doi.org/10.1016/S0166-0934(02)00033-2

Alam MM, Zaidi SZ, Malik SA, et al. Serology based disease status of Pakistani population infected with Hepatitis B virus. BMC Infect Dis. 2007 Dec;7(1):64-69. DOI: https://doi.org/10.1186/1471-2334-7-64

Khan MA, Ashraf M, Rehman A, Ali A, Ashraf M, Ditta A. Prevalence of HBV, HCV and HIV in blood donors at Liaquetpur. Prof Med J. 2006;13(01):23-26. DOI: https://doi.org/10.29309/TPMJ/2006.13.01.5050

Bangash MH, Bangash TH, Alam S. Prevalence of hepatitis B and hepatitis C among healthy blood donors at Kurram Agency. J Postgrad Med Inst. 2009;23:140–145.

Ahmad I, Khan SB, Rehman HU, Khan MH, Anwar S. Frequency of hepatitis B and hepatitis C among cataract patients. Gomal J Med Sci. 2006;4:2-9.

Khan TS, Rizvi F. Hepatitis B seropositivity among chronic liver disease patients in Hazara Division Pakistan. J Ayub Med Coll Abottabad. 2003;15:54–55.

Khan AJ Siddiqui TR. Prevalence of Hepatitis B and C screening in cases undergoing Elective eye surgery. Pak J Opthalmol. 2007;23(1):39–44.

Farooqi JI, Farooqi RJ. Relative frequency of hepatitis B and C virus infections in cases of hepatocellular carcinoma in North West Frontier Province. Pakistan. J Coll Physicians Surg Pak. 2000;10:128-30.

Published
2021-05-21
How to Cite
Khurram, M., Irshad, A., Alamgir, M., Ayub Awan, U., Syed, A., & Sadia, H. (2021). Epidemiological Survey of the Prevalence of HCV and HBV among the Factory Workers in the Periphery of Lahore. BioScientific Review, 3(1), 25-33. https://doi.org/10.32350/BSR.0301.03
Section
Research Articles