Assessment of Serum Urea and Creatinine Levels in Diabetic Patients
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Diabetic nephropathy is the leading cause of renal morbidity which occurs when chronic diabetes destroys the filtering system of the kidneys. Serum urea and creatinine are widely used as renal function test parameters. This study aims to assess the level of serum urea and creatinine in diabetic patients and their relationship with each other. The study was conducted in Ayub Teaching Hospital from September 15 to December 20, 2019. A total of 176 samples from confirmed diabetic patients were analyzed including 85 female and 91 male patients. Also, 83 control samples were taken for this study. Serum urea and creatinine levels were assessed to evaluate diabetic nephropathy in diabetic patients. SPSS (version 23) was used for statistical analysis. Pearson correlation analysis was used to check the relationship of blood sugar level, creatinine, and urea. Descriptive statistics (mean ± SD) were measured for the continuous variable. Scatter plot diagrams were added for the easy visualization and interpretation of the data. The significant level was set at p < 0.05. Out of the 176 diabetic samples, 32 had abnormally high serum creatinine and 66 had abnormal serum urea. In controls, one individual had high creatinine and three individuals had high serum urea. A significant increase in both urea and creatinine levels was observed in diabetic samples. Both serum urea and creatinine showed a strong positive correlation with the level of glucose and remained statistically significant (p < 0.01). Similarly, blood glucose level showed a strong correlation with the renal function test parameters. Hence, it was concluded that serum urea and creatinine are important parameters to assess kidney function in diabetes mellitus.
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Noor T, Hanif F, Kiran Z, et al. Relation of copeptin with diabetic and renal function markers among patients with diabetes mellitus progressing towards diabetic nephropathy. Arch Med Res. 2020;51(6):548–555. https://doi.org/10.1016/j.arcmed.2020.05.018
Sueud T, Hadi NR, Abdulameer R, Jamil DA, Al-Aubaidy HA. Assessing urinary levels of IL-18, NGAL and albumin creatinine ratio in patients with diabetic nephropathy. Diabetes Metab Syndr: Clin Res Rev. 2019;13(1):564–568. https://doi.org/10.1016/j.dsx.2018.11.022
Cerik I, Dindaş F, YILMAZ M. Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. Türk Kardiyoloji Derneği Arşivi. 2023;51(1);32–39. https://doi.org/10.5543/tkda.2022.77567
Murtadha NA, Sarhat ER, Salih AA. Evaluation of serum adiponectin and lipid profile in regular hemodialysis patients. Int J Special Education. 2022;37(3);10808–10815.
Sagoo MK, Gnudi L. Diabetic nephropathy: an overview. In: Gnudi L, Long D, eds. Methods in Molecular Biology. Humana, New York: Springer; 2020:3–7.
Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. BioMed Res Int. 2021;2021: e1497449 https://doi.org/10.1155/2021/1497449
Selby NM, Taal MW. An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. 2020;22:3–15. https://doi.org/10.1111/dom.14007
Pelle MC, Provenzano M, Busutti M, et al. Up-date on diabetic nephropathy. Life. 2022;12(8):e1202. https://doi.org/10.3390/life12081202
Lovic D, Piperidou A, Zografou I, Grassos H, Pittaras A, Manolis A. The growing epidemic of diabetes mellitus. Curr Vasc Pharmacol. 2020;18(2):104–109. https://doi.org/10.2174/1570161117666190405165911
Cho NH, Shaw JE, Karuranga S, et al. IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. https://doi.org/10.1016/j.diabres.2018.02.023
Adnan M, Aasim M. Prevalence of type 2 diabetes mellitus in adult population of pakistan: a meta-analysis of prospective cross-sectional surveys. Ann Glob Health. 2020;86(1):e7. https://doi.org/10.5334%2Faogh.2679
Basit A. The Diabetic Foot Worldwide: Pakistan. In: Boulton AJM, Rayman G, Wukich DK, eds. The Foot in Diabetes. 5th ed. Willey Online Library; 2020:47–49. https://doi.org/10.1002/9781119445821.ch4b
Sawaf H, Thomas G, Taliercio JJ, Nakhoul G, Vachharajani TJ, Mehdi A. Therapeutic advances in diabetic nephropathy. J Clin Med. 2022;11(2):e378. https://doi.org/10.3390/jcm11020378
Bhatia K, Misra P, Singh A, Mukherjee B, Ambade VN. Study of blood urea nitrogen (bun), serum creatinine in diabetic and non-diabetic patients in a tertiary care hospital. Int J Med Biomed Stud. 2019;3(4). https://doi.org/10.32553/ijmbs.v3i4.216
Pathan SB, Jawade P, Lalla P. Correlation of serum urea and serum creatinine in diabetics patients and normal individuals. Int J Clin Biochem Res. 2020;7(1):45–48. https://doi.org/10.18231/j.ijcbr.2020.009
Han S, Chen M, Cheng P, et al. A systematic review and meta-analysis of gut microbiota in diabetic kidney disease: Comparisons with diabetes mellitus, non-diabetic kidney disease, and healthy individuals. Front Endocrinol. 2022;13:e1018093. https://doi.org/10.3389/fendo.2022.1018093
Mali B, Nicholas PC. Jaffes' reaction for creatinine: kinetic study and spectrophotometric characteristics of the product of the reactions of creatinine, acetoacetate and creatinine and acetoacetate with alkaline picrate. Portland Press Ltd. Biochem Soc Trans. 1988;16(4):549–550. https://doi.org/10.1042/bst0160549
Richterich R, Küffer H. The determination of urea in plasma and serum by a urease/berthelot method, adapted to the greiner electronic selective analyzer GSA II (Author's Transl). Z Klin Chcm Klin Biochem. 1973;11(12):553–564. https://doi.org/10.1515/cclm.1973.11.12.553
Noor T, Hanif F, Kiran Z, et al. Relation of copeptin with diabetic and renal function markers among patients with diabetes mellitus progressing towards diabetic nephropathy. Arch Med Res. 2020;51(6):548–555. https://doi.org/10.1016/j.arcmed.2020.05.018
Sueud T, Hadi NR, Abdulameer R, Jamil DA, Al-Aubaidy HA. Assessing urinary levels of IL-18, NGAL and albumin creatinine ratio in patients with diabetic nephropathy. Diabetes Metab Syndr: Clin Res Rev. 2019;13(1):564–568. https://doi.org/10.1016/j.dsx.2018.11.022
Cerik I, Dindaş F, YILMAZ M. Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. Türk Kardiyoloji Derneği Arşivi. 2023;51(1);32–39. https://doi.org/10.5543/tkda.2022.77567
Murtadha NA, Sarhat ER, Salih AA. Evaluation of serum adiponectin and lipid profile in regular hemodialysis patients. Int J Special Education. 2022;37(3);10808–10815.
Sagoo MK, Gnudi L. Diabetic nephropathy: an overview. In: Gnudi L, Long D, eds. Methods in Molecular Biology. Humana, New York: Springer; 2020:3–7.
Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. BioMed Res Int. 2021;2021: e1497449 https://doi.org/10.1155/2021/1497449
Selby NM, Taal MW. An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. 2020;22:3–15. https://doi.org/10.1111/dom.14007
Pelle MC, Provenzano M, Busutti M, et al. Up-date on diabetic nephropathy. Life. 2022;12(8):e1202. https://doi.org/10.3390/life12081202
Lovic D, Piperidou A, Zografou I, Grassos H, Pittaras A, Manolis A. The growing epidemic of diabetes mellitus. Curr Vasc Pharmacol. 2020;18(2):104–109. https://doi.org/10.2174/1570161117666190405165911
Cho NH, Shaw JE, Karuranga S, et al. IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. https://doi.org/10.1016/j.diabres.2018.02.023
Adnan M, Aasim M. Prevalence of type 2 diabetes mellitus in adult population of pakistan: a meta-analysis of prospective cross-sectional surveys. Ann Glob Health. 2020;86(1):e7. https://doi.org/10.5334%2Faogh.2679
Basit A. The Diabetic Foot Worldwide: Pakistan. In: Boulton AJM, Rayman G, Wukich DK, eds. The Foot in Diabetes. 5th ed. Willey Online Library; 2020:47–49. https://doi.org/10.1002/9781119445821.ch4b
Sawaf H, Thomas G, Taliercio JJ, Nakhoul G, Vachharajani TJ, Mehdi A. Therapeutic advances in diabetic nephropathy. J Clin Med. 2022;11(2):e378. https://doi.org/10.3390/jcm11020378
Bhatia K, Misra P, Singh A, Mukherjee B, Ambade VN. Study of blood urea nitrogen (bun), serum creatinine in diabetic and non-diabetic patients in a tertiary care hospital. Int J Med Biomed Stud. 2019;3(4). https://doi.org/10.32553/ijmbs.v3i4.216
Pathan SB, Jawade P, Lalla P. Correlation of serum urea and serum creatinine in diabetics patients and normal individuals. Int J Clin Biochem Res. 2020;7(1):45–48. https://doi.org/10.18231/j.ijcbr.2020.009
Han S, Chen M, Cheng P, et al. A systematic review and meta-analysis of gut microbiota in diabetic kidney disease: Comparisons with diabetes mellitus, non-diabetic kidney disease, and healthy individuals. Front Endocrinol. 2022;13:e1018093. https://doi.org/10.3389/fendo.2022.1018093
Mali B, Nicholas PC. Jaffes' reaction for creatinine: kinetic study and spectrophotometric characteristics of the product of the reactions of creatinine, acetoacetate and creatinine and acetoacetate with alkaline picrate. Portland Press Ltd. Biochem Soc Trans. 1988;16(4):549–550. https://doi.org/10.1042/bst0160549
Richterich R, Küffer H. The determination of urea in plasma and serum by a urease/berthelot method, adapted to the greiner electronic selective analyzer GSA II (Author's Transl). Z Klin Chcm Klin Biochem. 1973;11(12):553–564. https://doi.org/10.1515/cclm.1973.11.12.553
Liu X, Du H, Sun Y, Shao L. Role of abnormal energy metabolism in the progression of chronic kidney disease and drug intervention. Renal Failur. 2022;44(1):790–805. https://doi.org/10.1080/0886022X.2022.2072743
Kamal A. Impact of diabetes on renal function parameters. Ind J Fund Appl Life Sci. 2014;4(3):411–416.
Edremitlioğlu M, Andiç MF, Sayın DB, Korkut O, Kısa Ü. Quercetin, a powerful antioxidant bioflavonoid, attenuates renal dysfunction in long-term experimental diabetes mellitus. Marmara Med J. 2011;24(2):88–99
Ekun OA, Fagbemi OF, Adejumo EN, et al. Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus. Afr Health Sci. 2022;22(3):296–306. https://doi.org/10.4314/ahs.v22i3.31
Bamanikar S, Bamanikar A, Arora A. Study of serum urea and creatinine in diabetic and nondiabetic patients in a tertiary teaching hospital. J Med Res. 2016;2(1):12–15.
Ahmed TI, Bhola J, Shabaz M, et al. Fuzzy logic-based systems for the diagnosis of chronic kidney disease. BioMed Res Int. 2022;2022:e2653665. https://doi.org/10.1155/2022/2653665
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