Cushing’s Syndrome (CS) in Children: Pathophysiology, Clinical Features, Diagnostic, and Therapeutic Strategies

  • Sana Ashraf Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
  • Shakeela Parveen 1Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan;2Department of Zoology, University of Agriculture, Faisalabad, Pakistan
  • Saba Ashraf Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
  • Uzma Batool Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
  • Mehwish Sultana Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
  • Urwah Ishaque Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
  • Zainab Shafqat Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
  • Saman Shabbir Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
  • Zainab Riaz Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
  • Zunaira Faiz Department of Zoology, The Government Sadiq College Women, University of Bahawalpur, Pakistan
DOI: https://doi.org/10.32350/BSR.52.04
Keywords: clinical features, Cushing’s Syndrome (CS), diagnostic features, hypercortisolism, pathophysiology, therapeutic strategies

Abstract

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A rare condition known as Cushing’s Disease (CD) causes increased morbidity or mortality. It is an endocrine illness that presents differently from other endocrine disorders, making it difficult for doctors to control. Hence, early detection and treatment are essential. Significant fetal and mental complications during pregnancy are linked to Cushing’s Syndrome (CS). Except in the late trimester, surgery is its preferred method of treatment during pregnancy, with medication therapy as a backup. Therapeutic methods such as anti-cortisol medication, bilateral adrenalectomy, or radiation procedures may, therefore, be required to prevent long-term dangers of hypercortisolism, such as hirsutism, moon face, facial plethora, and obesity. Endogenous hypercortisolism increases the risk of cardiovascular metabolic symptoms, osteoporosis, respiratory diseases, psychological difficulties, and infections, while also inducing a high rate of morbidity or mortality.

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Published
2023-06-27
How to Cite
Ashraf, S., Parveen, S., Ashraf, S., Batool, U., Sultana, M., Ishaque, U., Shafqat, Z., Shabbir, S., Riaz, Z., & Faiz, Z. (2023). Cushing’s Syndrome (CS) in Children: Pathophysiology, Clinical Features, Diagnostic, and Therapeutic Strategies. BioScientific Review, 5(2), 26-38. https://doi.org/10.32350/BSR.52.04
Issue
Vol 5 No 2: June 2023
Section
Review Article

Copyright (c) 2023 Sana Ashraf, Dr Shakeela Parveen, Saba Ashraf, Uzma Batool, Mehwish Sultana, Urwah Ishaque, Zainab Shafqat, Saman Shabbir, Zainab Riaz, Zunaira Faiz

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