The Cardioprotective Effect of Allium sativum on C-Reactive Protein and Cardiac Structure in Rabbits
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Background. Diet and lifestyle comprise major risk factors in the development of various human diseases, including atherosclerosis. C- Reactive protein (CRP) is one of the possible markers of vascular inflammation. High CRP levels can predict the long-term risk of cardiovascular diseases. The current study aimed to evaluate the ameliorating effect of Allium sativum against high-fat diet-induced damage to heart structure and CRP levels.
Methodology. A total of 16 rabbits were randomly assigned to 4 groups (n=4 each). Group 1 served as the control group and it was fed with standard diet. Whereas, the remaining 3 groups were experimental groups. Group 2 was fed with high fat diet, Group 3 was fed with high fat diet supplemented with 5% Allium sativum, and Group 4 was fed with high fat diet supplemented with 10% A. sativum. The experiment was conducted for 4 weeks.
Results. Mild myocardial congestion was observed in the heart tissues of rabbits in Group 2 fed with high fat diets. Group 3 and Group 4, fed with 5% and 10% A. sativum respectively and with a high fat diet, showed no myocardial congestion. This indicates the cardio-protective potential of A. sativum. Group 2 showed a significant (p<0.05) increase in CRP levels as compared to control.
Conclusion. The results showed that A. sativum demonstrated a beneficial effect on both heart structure and CRP levels, suggesting its potential as an adjunct therapy for cardiovascular diseases.
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