Plant-Extract of Mimusops elengi leaves and Flower-Mediated ZnO Nanoparticles: Synthesis, Characterization, and Biomedical Applications
Abstract
Abstract Views: 0The current study aims to employ an ecologically sustainable method, utilizing a plant-based extract derived from Mimusops elengi as both a reducing and capping agent. Synthesis of zinc oxide nanoparticles (ZnO NPs) was done from aqueous leaves and flower extracts of Mimusops elengi. Different spectroscopic techniques were used to characterize these biosynthesized (ZnO NPs) zinc oxide nanoparticles like UV-visible, FTIR, XRD, SEM, and EDX techniques. UV-visible spectroscopy showed the absorption wavelength of ZnO NPs at 353nm (leaves extracts) and 365nm (flowers extracts). FTIR spectra showed the absorption frequency of different functional groups present in plant extract along with ZnO peak at 637cm-1 (leaves extracts) and 643cm-1 (flowers extracts). XRD results revealed the hexagonal structure and crystalline nature of biosynthesized ZnO NPs. The average grain size calculated for ZnO NPs of leaves and flower extracts was 10.37 and 15.52nm, respectively. SEM analysis showed a hexagonal shape. EDX confirmed the formation and purity of ZnO NPs by showing an abundant % of zinc and oxygen atoms. The significant bactericidal efficacy of biosynthesized ZnO NPs was found against pathogens Escherichia coli and Staphylococcus aureus. When compared to ZnO nanoparticles from flower extracts and biosynthesized ZnO nanoparticles from leaf extract exhibited substantial suppression. ZnO-NPs synthesized from leaves and flower extracts of Mimusops elengi can be subjugated for biomedical and ecologically sustainable applications.
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Treguer M, De Cointet C, Remita H, et al. Dose rate effects on radiolytic synthesis of gold− silver bimetallic clusters in solution. J Phyl Chem. 1998;102(22):4310–4321. https://doi.org/10.1021/jp981467n
LaConte L, Nitin N, Bao G. Magnetic nanoparticle probes. Mater Today. 2005;8(5):32–38. https://doi.org/10.1016/S1369-7021(05) 00893-X
Iqbal J, Abbasi BA, Mahmood T, Hameed S, Munir A, Kanwal S. Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications. Appl Organomet Chem. 2019;33(8):e4950. https://doi.org/10.1002/ aoc.4950
Altavilla C, Ciliberto E. Inorganic Nanoparticles: Synthesis, Applications, and Perspectives. CRC Press; 2017.
Wang J, Cao J, Fang B, Lu P, Deng S, Wang H. Synthesis and characterization of multipod, flower-like, and shuttle-like ZnO frameworks in ionic liquids. Mat Lett. 2005;59(11):1405–1408. https://doi.org/10.1016/j.matlet.2004.11.062
Bacaksiz E, Parlak M, Tomakin M, Özçelik A, Karakız M, Altunbaş M. The effects of zinc nitrate, zinc acetate and zinc chloride precursors on investigation of structural and optical properties of ZnO thin films. J Alloys Comp. 2008;466(1-2):447–450. https://doi.org/10.1016/j. jallcom.2007.11.061
Abbasi BA, Iqbal J, Mahmood T, Qyyum A, Kanwal S. Biofabrication of iron oxide nanoparticles by leaf extract of Rhamnus virgata: characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials. Appl Organomet Chem. 2019;33(7):e4947. https://doi.org/10.1002/aoc.4947
Zhang H, Chen B, Jiang H, Wang C, Wang H, Wang X. A strategy for ZnO nanorod mediated multi-mode cancer treatment. Biomaterials. 2011;32(7):1906–1914. https://doi.org/10.1016/j.biomaterials.2010. 11.027
Iravani S, Korbekandi H, Mirmohammadi SV, Zolfaghari B. Synthesis of silver nanoparticles: chemical, physical and biological methods. Res Pharm Sci. 2014;9(6):385–406.
De Melo CG, Pereira LHDS, Da Costa LAG, et al. Experimental methodologies for the obtainment of momordica charantia l. extracts with anthelminth activity: a review. Pharmaco Rev. 2022;16(32):82–89.
Kumar DS, Xavier TF. Antibacterial activity, biosynthesis and characterization of silver nanoparticle from the leaf extract of (L.) Nees. andrographis echioides. Asian J Pharm Pharmacol. 2019;5(1):95–100. https://doi.org/10.31024/ajpp.2019.5.1.14
Begum NA, Mondal S, Basu S, Laskar RA, Mandal D. Biogenic synthesis of Au and Ag nanoparticles using aqueous solutions of Black Tea leaf extracts. Colloids Surf B. 2009;71(1):113–118. https://doi.org/10.1016/j.colsurfb.2009.01.012
Kadam PV, Yadav KN, Deoda RS, Shivatare RS, Patil MJ. Mimusops elengi: a review on ethnobotany, phytochemical and pharmacological profile. J Pharmaco Phytochem. 2012;1(3):64–74.
Zahid H, Rizwani GH, Shareef H, Mahmud S, Ali T. Hypoglycemic and hypolipidemic effects of Mimusops elengi Linn, extracts on normoglycaemic and alloxaninduced diabetic rats. Int J Pharmal Biol Arch. 2012;3(1):56–62.
Gami B, Pathak S, Parabia M. Ethnobotanical, phytochemical and pharmacological review of Mimusops elengi Linn. Asian Pa J Trop Biomed. 2012;2(9):743–748. https://doi.org/10.1016/S2221-1691(12)60221-4
Nagajyothi P, Sreekanth T, Tettey CO, Jun YI, Mook SH. Characterization, antibacterial, antioxidant, and cytotoxic activities of ZnO nanoparticles using Coptidis Rhizoma. Bioorg Med Chem Lett. 2014;24(17):4298–4303. https://doi.org/10.1016/j.bmcl.2014.07.023
Gurgur E, Oluyamo S, Adetuyi A, Omotunde O, Okoronkwo A. Green synthesis of zinc oxide nanoparticles and zinc oxide–silver, zinc oxide–copper nanocomposites using Bridelia ferruginea as biotemplate. SN Appl Sci. 2020;2:1–12. https://doi.org/10.1007/s42452-020-2269-3
Talam S, Karumuri SR, Gunnam N. Synthesis, characterization, and spectroscopic properties of ZnO nanoparticles. Int Scholar Res Not. 2012;2012:e372505. https://doi.org/10.5402/2012/372505
Vijayalakshmi U, Chellappa M, Anjaneyulu U, Manivasagam G, Sethu S. Influence of coating parameter and sintering atmosphere on the corrosion resistance behavior of electrophoretically deposited composite coatings. Mat Manufac Proc. 2016;31(1):95–106. https://doi.org/10.1080/10426914.2015.1070424
Stan M, Popa A, Toloman D, Silipas T-D, Vodnar DC. Antibacterial and antioxidant activities of ZnO nanoparticles synthesized using extracts of Allium sativum, Rosmarinus officinalis and Ocimum basilicum. Acta Metallur Sinica. 2016;29:228–236. https://doi.org/10.1007/s40195-016-0380-7
Huang J, Li Q, Sun D, et al. Biosynthesis of silver and gold nanoparticles by novel sundried Cinnamomum camphora leaf. Nanotechnology. 2007;18(10):e105104. https://doi.org/10.1088/0957-4484/18/10/105104
Shamhari NM, Wee BS, Chin SF, Kok KY. Synthesis and characterization of zinc oxide nanoparticles with small particle size distribution. Acta Chim Sloven. 2018;65(3):578–585. https://doi.org/10.17344/acsi.2018.4213
Jayarambabu N, Kumari BS, Rao KV, Prabhu Y. Beneficial role of zinc oxide nanoparticles on green crop production. Int J Multidiscip Adv Res Trends. 2015;2:273–282.
Jain N, Bhargava A, Majumdar S, Tarafdar J, Panwar J. Extracellular biosynthesis and characterization of silver nanoparticles using Aspergillus flavus NJP08: a mechanism perspective. Nanoscale. 2011;3(2):635–641. https://doi.org/10.1039/C0NR00656D
Barzinjy AA, Azeez HH. Green synthesis and characterization of zinc oxide nanoparticles using Eucalyptus globulus Labill. leaf extract and zinc nitrate hexahydrate salt. SN Appl Scis. 2020;2(5):e991. https://doi.org/10.1007/s42452-020-2813-1
Muhammad W, Ullah N, Haroon M, Abbasi BH. Optical, morphological and biological analysis of zinc oxide nanoparticles (ZnO NPs) using Papaver somniferum L. RSC Adv. 2019;9(51):29541–29548. https://doi.org/10.1039/C9RA04424H
Khatami M, Alijani HQ, Heli H, Sharifi I. Rectangular shaped zinc oxide nanoparticles: green synthesis by Stevia and its biomedical efficiency. Ceram Int. 2018;44(13):15596–15602. https://doi.org/10.1016/j.ceramint.2018.05.224
Khan MA, Abbasi BH, Shinwari ZK. Thidiazuron enhanced regeneration and silymarin content in Silybum marianum L. Pak J Bot. 2014;46(1):185–190.
Ramesh M, Anbuvannan M, Viruthagiri G. Green synthesis of ZnO nanoparticles using Solanum nigrum leaf extract and their antibacterial activity. Spectrochim Acta A Mol Biomol Spectrosc. 2015;136:864–870. https://doi.org/10.1016/j.saa.2014.09.105
Kumar SS, Venkateswarlu P, Rao VR, Rao GN. Synthesis, characterization and optical properties of zinc oxide nanoparticles. Int Nano Lett. 2013;3:e30. https://doi.org/10.1186/2228-5326-3-30
Fakhari S, Jamzad M, Fard HK. Green synthesis of zinc oxide nanoparticles: a comparison. Green Chem Lett Rev. 2019;12(1):19–24. https://doi.org/10.1080/17518253.2018.1547925
Raghupathi KR, Koodali RT, Manna AC. Size-dependent bacterial growth inhibition and mechanism of antibacterial activity of zinc oxide nanoparticles. Langmuir. 2011;27(7):4020–4028. https://doi.org/10.1021/la104825u
Ratney YJJ, David SB. Antibacterial activity of zinc oxide nanoparticles by sonochemical method and green method using Zingiber officinale. Green Chem Tech Lett. 2016;2:11–15. https://doi.org/10.18510/gctl.2016.212
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