Phytochemistry, Nutritional, and Pharmacological Potential of Citrus Limonum

  • Faiza Qurban Department of Chemistry, Lahore Garrison University, Lahore, Pakistan
  • Shabbir Hussain Institute of Chemistry, Khwaja Fareed University of Engineering and Information Technology Rahim Yar Khan, Pakistan
  • Muhammad Waqas Department of Chemistry, Lahore Garrison University, Lahore, Pakistan
  • Hafiza Hadiya Shahzad Department of Chemistry, Lahore Garrison University, Lahore, Pakistan
  • Aqsa Rukhsar Department of Chemistry, Lahore Garrison University, Lahore, Pakistan
  • Atif Javed Department of Chemistry, Lahore Garrison University, Lahore, Pakistan
Keywords: dietary, lemon, medicinal, nutritional, vitamin C

Abstract

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The current research aimed to provide an overview of the phytochemical configuration, nutritional value, and therapeutic uses of Citrous Limonum (lemon). Its fruit contains a variety of phytochemicals including citric acid, polyphenols, terpenes, limonene, flavonoids, vitamin C, sugar, pectin, citric acid, malic acid, flavonoids, carotenoids, terpineol, fellander, camhenium, citrain, calcium oxalates, and mucilages. Vitamin C is abundant in citrous fruits, as well as macronutrients (dietary fibre and simple sugar) and micronutrients (copper, magnesium, phosphorus, calcium, potassium, pantothenic acid, riboflavin, vit B6 niacin thiamin, and folate). Lemon oil is composed of 70% limonene and 20% monoterpenes, along with significant amounts of aldehydes, such as citral, alcohols (linalool), and esters (coumarin). Lemon peel contains high concentrations of flavonoids, glycosides, coumarins, steroids (beta, gamma, sitosterol), dietary fibers, carbs, and volatile oils, all of which are necessary for good health and appropriate development. However, citrus fruits are low in calories, salts, and cholesterol. They find uses in herbal remedies due to their antioxidant, antifungal, anti-cholesterol, anticancer, antiulcer, antidiabetic, antibacterial, and anti-inflammatory characteristics. It is also important to mention that the excessive use of lemon may also be associated with some risks, such as the lowering of sperm count.

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References

Javed M, Bibi R, Nazir K, Hussain S. Phytochemistry of ziziphus mauritiana; its antioxidant and antimicrobial potential. Advanc Life Sci. 2022;9(2):157–162.

Naseer S, Hussain S, Naeem N, Pervaiz M, Rahman M. The phytochemistry and medicinal value of Psidium guajava (guava). Clinic Phytosci. 2018;4(1):1–8. https://doi.org/10.1186/s40816-018-0093-8

Kamran M, Hussain S, Abid MA, et al. Phytochemical composition of moringa oleifera its nutritional and pharmacological importance. Postepy Biol Komorki. 2020;47(3):321–334.

Rasheed RB, Hussain S, Syed SK. Phytochemistry, nutritional and medicinal value of kiwi fruit. Postepy Biol Komorki. 2021;48(2):147–165.

Rehman A, Hussain S, Javed M, et al. Chemical composition and remedial perspectives of Hippophae rhamnoides linn. Postepy Biol Komorki. 2018;45(3):199–209.

Naseer S, Hussain S, Zahid Z. Nutritional and antioxidant potential of common vegetables in Pakistan. RADS J Biol Res Appl Sci. 2019;10(1):36–40. https://doi.org/10.37962/jbas.v10i1.146

Grover J, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharm. 2002;81(1):81–100. https://doi.org/10.1016/S0378-8741(02)00059-4

Shariff N, Sudarshana M, Umesha S, Hariprasad P. Antimicrobial activity of Rauvolfia tetraphylla and Physalis minima leaf and callus extracts. Afri J Biotechnol. 2006;5(10):946–950.

Ekta1, Kamalesh SK, Kousik MD, Tapas B. Role of yoga in primary dysmenorrhoea. J Pharm Sci Innov. 2014;3(5):410–412. https://doi.org/10.7897/2277-4572.035184

Ranganna S, Govindarajan V, Ramana K, Kefford J. Citrus fruits—varieties, chemistry, technology, and quality evaluation. Part II. Chemistry, technology, and quality evaluation. a. Chemistry. Critic Rev Food Sci Nutr. 1983;18(4):313–386. https://doi.org/10.1080/10408398309527366

Jana P, Sureshrao PA, Sahu RS. Medicinal and health benefits of lemon. J Sci Technol. 2020;6:16–20. https://doi.org/10.46243/jst.2020.v6.i1.pp16-20

Nicolosi E, Deng Z, Gentile A, La Malfa S, Continella G, Tribulato E. Citrus phylogeny and genetic origin of important species as investigated by molecular markers. Theor Appl Genet. 2000;100(8):1155–1166. https://doi.org/10.1007/s001220051419

de Araújo EF, de Queiroz LP, Machado MA. What is citrus? taxonomic implications from a study of cp-DNA evolution in the tribe Citreae (Rutaceae subfamily Aurantioideae). Organ Divers Evol. 2003;3(1):55–62. https://doi.org/10.1078/1439-6092-00058

Anitei S. Where did citrus fruits originate from? Softpedia Web site. https://news.softpedia.com/news/Where-Did-Citrus-Fruits-Originate-From-67365.shtml. Updated October 2, 2007. Accessed November 16, 2023.

Cororaton CB, Orden D, Peterson E. Economic impact of potential US regulatory decisions concerning imports of Argentine Lemons. GII Working Paper No. 2011-1; 2011. https://aaec.vt.edu/content/dam/aaec_vt_edu/people/faculty/URLs/GII_WP2011-1.pdf

Ciriminna R, Fidalgo A, Scurria A, et al. The case for a lemon bioeconomy. Adv Sustain Syst. 2020;4(4):e2000006. https://doi.org/10.1002/adsu.202000006

Siddique IM, Sharif N, Ghaffar A, Naseer M, Noreen A, Akhtar N. Studies on the yield, quality and biochemical characters of five less seeded strains of kinnow mandarin. Pak J Agricul Res. 2023;36(131):10–19.

Olaniyan A. Development of a small scale orange juice extractor. J Food Sci Technol. 2010;47(1):105–108. https://doi.org/10.1007/s13197-010-0002-8

Hussain S, Javed M, Abid MA, et al. Prunus Avium L.; phytochemistry, nutritional and pharmacological review. Advanc Life Sci. 2021;8(4):307–314.

Naseer S, Hussain S, Abid A. Betalain as a food colorant: its sources, chemistry and health benefits: chemistry of betalain and its role as food colorant. Proc Pak Acad Sci. 2019;56(2):1–08.

Hussain S, Tanvir M, Ahmad M, Munawar KS. Phytochemical composition of mint (Mentha), its nutritional and pharmacological potential. Lahore Garrison Univ J Life Sci. 2021;5(04):241–258. https://doi.org/10.54692/lgujls.2021.0504188

Siddiqua A, Hussain S, Syed SK. Phytochemistry, nutritional and medicinal importance of Almond. Postepy Biol Komorki. 2021;48(2):167–180.

Bland J. Phytonutrition, phytotherapy, and phytopharmacology. Alternat Therap Health Med. 1996;2(6):73–76.

Rauf A, Uddin G, Ali J. Phytochemical analysis and radical scavenging profile of juices of Citrus sinensis, Citrus anrantifolia, and Citrus limonum. Org Med Chem Lett. 2014;4(1):1–3. https://doi.org/10.1186/2191-2858-4-5

Silalahi J. Anticancer and health protective properties of citrus fruit components. Asia Pacific J Clinic Nutr. 2002;11(1):79–84. https://doi.org/10.1046/j.1440-6047.2002.00271.x

Anandakumar P, Kamaraj S, Vanitha MK. D‐limonene: a multifunctional compound with potent therapeutic effects. J Food Biochem. 2021;45(1):e13566. https://doi.org/10.1111/jfbc.13566

Vekiari SA, Protopapadakis EE, Papadopoulou P, Papanicolaou D, Panou C, Vamvakias M. Composition and seasonal variation of the essential oil from leaves and peel of a Cretan lemon variety. J Agricul Food Chemi. 2002;50(1):147–153. https://doi.org/10.1021/jf001369a

Al-Qudah TS, Zahra U, Rehman R, et al. Lemon as a source of functional and medicinal ingredient: a review. Int J Chem Biochem Sci. 2018;14:55–61.

Erdogan S, Celik S, Erdogan Z. Seasonal and locational effects on serum, milk, liver and kidney chromium, manganese, copper, zinc, and iron concentrations of dairy cows. Biol Trace Elem Res. 2004;98(1):51–61. https://doi.org/10.1385/BTER:98:1:51

Tandoğan B, Ulusu NN. Importance of calcium. Turk J Med Sci. 2005;35(4):197–201.

Esen A, Scora RW. Amylase polymorphism in Citrus and some related genera. Am J Bot. 1977;64(3):305–309. https://doi.org/10.1002/j.1537-2197.1977.tb15731.x

Albrigo LG, Carter RD. Structure of citrus fruits in relation to processing. In: Nagy S, Shaw PE, Veldhuis MK, eds. Citrus Science and Technology. AVI Publishing; 1977:38–73.

Ramana K, Govindarajan V, Ranganna S, Kefford J. Citrus fruits—varieties, chemistry, technology, and quality evaluation. Part I: Varieties, production, handling, and storage. Critic Rev Food Sci Nutr. 1981;15(4):353–431. https://doi.org/10.1080/10408398109527321

Nagy S, American Chemical Society, Attaway J. Citrus nutrition and quality. Based on a symposium sponsored by the Div. of Agricultural and Food Chemistry at the 179th Meeting of the American Chemical Society, Houston, Tex., Mar 26, 1980. Alliance of Agricultural Information Services; 1980. https://www.sidalc.net/search/Record/unfao:609299/Description

Rouseff RL, Nagy S. Health and nutritional benefits of citrus fruit components. Food Technol. 1994;48(11):125–132.

Clay WD, Economos C. Nutritional and health benefits of citrus fruits. Nutr Agricul. 1999;24:11–18.

Whitney E, Rolfes SR. Understanding Nutrition. Cengage Learning; 2018.

Azar AP, Nekoei M, Larijani K, Bahraminasab S. Chemical composition of the essential oils of Citrus sinensis cv. valencia and a quantitative structure-retention relationship study for the prediction of retention indices by multiple linear regression. J Serb Chem Soc. 2011;76(12):1627–1637. https://doi.org/10.2298/JSC101218141A

Al-Snafi AE. Nutritional value and pharmacological importance of citrus species grown in Iraq. IOSR J Pharm. 2016;6(8):76–108.

Mohanapriya M, Ramaswamy L, Rajendran R. Health and medicinal properties of lemon (Citrus limonum). Int J Ayur Herb Med. 2013;3(1):1095–1100.

Dostalova L, Detvanova L, Kalhotka L. Antimicrobial activity of aqueous herbal extracts. MendelNet. 2014;2:403–406.

Dhiman A, Nanda A, Ahmad S, Narasimhan B. In vitro antimicrobial status of methanolic extract of Citrus sinensis Linn. fruit peel. Chronic Young Sci. 2012;3(3):e204

Jakhar RS. A review study on nutritional and medicinal importance of Lemon. Int J Innov Res Comput Sci Technol. 2021;9(5):87–91.

Barghouthy Y, Somani BK. Role of citrus fruit juices in prevention of kidney stone disease (KSD): a narrative review. Nutrients. 2021;13(11):e4117. https://doi.org/10.3390/nu13114117

Corrales M, Doizi S, Barghouthy Y, Traxer O, Daudon M. Classification of stones according to Michel Daudon: a narrative review. European Urol Focus. 2021;7(1):13–21. https://doi.org/10.1016/j.euf.2020.11.004

Gridley CM, Sourial MW, Lehman A, Knudsen BE. Medical dissolution therapy for the treatment of uric acid nephrolithiasis. World J Urol. 2019;37:2509–2515. https://doi.org/10.1007/s00345-019-02688-9

Hassan V, Saleem M, Shaffi N, Din K, Qasier M, Asfandyar. Lemon grass: botany, ethnobotany and chemistry-a review. Pak J Weed Sci Res. 2007;13(1-2):129–134.

Sawamura M, Son U-S, Choi H-S, et al. Compositional changes in commercial lemon essential oil for aromatherapy. Int J Aromather. 2004;14(1):27–36. https://doi.org/10.1016/j.ijat.2004.02.001

Malleshappa P, Kumaran RC, Venkatarangaiah K, Parveen S. Peels of citrus fruits: a potential source of anti-inflammatory and anti-nociceptive agents. Pharm J. 2018;10(6s):S172–S178. http://dx.doi.org/10.5530/pj.2018.6s.30

Shivhare S, Malviya K, Malviya KS, Jain V. A review: natural skin lighting and nourishing agents. Res J Top Cosmet Sci. 2013;4(1):21–25.

Avello M, Jofré P, Pastene E, Fernández P. Use of citrus limon L.(lemon) in treating blood pressure sudden rises. Int J Pharm Phytoch Res. 2014;6(3):606–611.

Kato Y, Domoto T, Hiramitsu M, et al. Effect on blood pressure of daily lemon ingestion and walking. J Nutr Metabol. 2014;2014:e12684. https://doi.org/10.1155/2014/912684

Ajugwo AO, Erhabor T, Mokogwu T, Digban K, Ojieh G, Nnatuanya I. Nutritional value of lime and lemon in hypercholesterolaemic induced rats. Asian J Med Sci. 2012;3(1):13–16. https://doi.org/10.3126/ajms.v3i1.5450

Aras B, Kalfazade N, Tuğcu V, et al. Can lemon juice be an alternative to potassium citrate in the treatment of urinary calcium stones in patients with hypocitraturia? a prospective randomized study. Urol Res. 2008;36:313–317. https://doi.org/10.1007/s00240-008-0152-6

Dhanavade MJ, Jalkute CB, Ghosh JS, Sonawane KD. Study antimicrobial activity of lemon (Citrus lemon L.) peel extract. Br J Pharmacol Toxicol. 2011;2(3):119–122.

Onawunmi GO. Evaluation of the antifungal activity of lemon grass oil. Int J Crude Drug Res. 1989;27(2):121–126. https://doi.org/10.3109/13880208909053950

Campêlo LML, Lima SGd, Feitosa CM, Freitas RMd. Evaluation of central nervous system effects of Citrus limon essential oil in mice. Rev Bras Farmacogn. 2011;21(4):668–673. https://doi.org/10.1590/S0102-695X2011005000086

Sridharan B, Michael ST, Arya R, Roopan SM, Ganesh RN, Viswanathan P. Beneficial effect of Citrus limon peel aqueous methanol extract on experimentally induced urolithic rats. Pharmaceut Biol. 2016;54(5):759–769. http://dx.doi.org/10.3109/13880209.2015.1079724

Rafique S, Hassan SM, Mughal SS, et al. Biological attributes of lemon: a review. J Addic Med Ther Sci. 2020;6(1):30–34.

Campêlo LML, e Sá CG, De Almeida AA, et al. Sedative, anxiolytic and antidepressant activities of Citrus limon (Burn) essential oil in mice. Die Pharm- Int J Pharm Sci. 2011;66(8):623–627. https://doi.org/10.1691/ph.2011.1508

Sah AN, Joshi A, Juyal V, Kumar T. Antidiabetic and hypolipidemic activity of Citrus medica Linn. seed extract in streptozotocin induced diabetic rats. Pharm J. 2011;3(23):80–84. https://doi.org/10.5530/pj.2011.23.12

Umashanker M, Shruti S. Traditional Indian herbal medicine used as antipyretic, antiulcer, anti-diabetic and anticancer: a review. Int J Res Pharm Chem. 2011;1(4):1152–1159.

Nagaraju B, Anand S, Ahmed N, Chandra JNS, Ahmed F, Padmavathi G. Antiulcer activity of aqueous extract of Citrus medica Linn. fruit against ethanol induced ulcer in rats. Adv Biol Res. 2012;6(1):24–29.

Bhavitavya B, Asdaq SMB, Asad M, Prasad S. Antiulcer activity of Lemon (Citrus limon) fruit juice and its interaction with conventionally used antiulcer drugs in rats. Nat Prod J. 2012;2(1):61–68.

Archana NS, Vijay J, Melkani AB. Analgesic activity of fruit decoction of citrus medica Linn. J Pharm Res. 2010;3(9):2119–2121.

Parmar D, Sharma D, Pant M, Dan S. Phytochemical composition and in vitro antioxidant activities of the genus Citrus peel extracts: a systematic review. Int Res J Modern Eng Technol Sci. 2020;2(9):953–961.

Garg H, Shrivastava A, Choudhary A. Flavonoids from lemon & tea as effective inhibitors against carcinogenesis. National Seminar on Innovations in Science & Technology for Inclusive Development; 2014. https://tinyurl.com/2vjc88rc

Rahayu VG, Hanizar E. The effect of lemon (Citrus limon) extracts on the quantity and quality of mice (Mus musculus) sperm. Elkawnie. 2022;7(2):300–316.

Shalaby NM, Abd-Alla HI, Ahmed HH, Basoudan N. Protective effect of Citrus sinensis and Citrus aurantifolia against osteoporosis and their phytochemical constituents. J Med Plants Res. 2011;5(4):579–588.

Loizzo MR, Tundis R, Bonesi M, et al. Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti‐cholinesterase activities. J Sci Food Agric. 2012;92(15):2960–2967. https://doi.org/10.1002/jsfa.5708

Muthiah P. In vitro xanthine oxidase inhibitory activity of leaves, fruits and peel extracts of citrus aurantium, citrus limetta and citrus limon. Int J Phytoph. 2012;2(3):77–80.

Wabner CL, Pak CY. Effect of orange juice consumption on urinary stone risk factors. J Urol. 1993;149(6):1405–1408. https://doi.org/10.1016/S0022-5347(17)36401-7

Patel S, Patel J, Patel M, Sen D. Say yes to warm for remove harm: amazing wonders of two stages of water. Eur J Pharm Med Res. 2015;2(4):444–460.

Hashemipour M, Kargar M, Ghannadi A, Kelishadi R. The effect of citrus aurantifolia (Lemon) peels on cardiometabolic risk factors and markers of endothelial function in adolescents with excess weight: a triple-masked randomized controlled trial. Med J Islam Repub Iran. 2016;30:e429.

Shetty P, Mooventhan A, Nagendra HR. Does short-term lemon honey juice fasting have effect on lipid profile and body composition in healthy individuals? J Ayurveda Integr Med. 2016;7(1):11–13. https://doi.org/10.1016/j.jaim.2016.03.001

Amandeep S, Bilal AR, Bevguni A. In vitro antibiotic activity of isolated volatile oil of Citrus sinensis. Int J Pharm Res Develop. 2009;7:1–4.

Published
2024-09-04
How to Cite
1.
Qurban F, Hussain S, Waqas M, Hadiya Shahzad H, Rukhsar A, Javed A. Phytochemistry, Nutritional, and Pharmacological Potential of Citrus Limonum. Sci Inquiry Rev. [Internet]. 2024Sep.4 [cited 2024Nov.21];8(3):1-23. Available from: https://journals.umt.edu.pk/index.php/SIR/article/view/3964
Section
Review Article