Investigating the Impact of Environmental Toxicology of Heavy Metals in Fish: A Study of Rivers of Pakistan
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The global concern of heavy metal toxicity has affected all nations, as the discharge of agricultural runoff and untreated industrial waste into water bodies, including rivers, leads to environmental toxicology. This increased level of heavy metals poses risks not only for marine life but also to those who consume them. While fish is an important protein source, consuming contaminated fish containing high levels of heavy metals can have severe adverse effects on human health. Therefore, it is crucial to address these pollution sources effectively in Pakistan, where a significant portion of the population relies on agriculture and fishing for their living. The country's rapid industrialization and urbanization have substantially increased pollutants in its rivers and other water bodies. The current body of research has indicated that the elevated levels of heavy metals in the ecosystem, including the Indus River, pose a significant threat to the local ecosystem and the well-being of marine life. Heavy metal pollution in Pakistani rivers originates from multiple sources, such as industrial effluents, agricultural runoff, and municipal waste. The unregulated discharge of industrial waste into rivers is a major contributor to heavy metal pollution in Pakistani rivers. Moreover, the excessive and uncontrolled use of fertilizers and pesticides in agriculture equally contributes to the contamination of rivers with heavy metals. The current study is a review article, which provides a comprehensive explanation of how environmental toxicology affects the ecosystem, especially concerning the rivers of Pakistan.
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Angriani P, Sumarmi, Ruja IN, Bachri S. River management: the importance of the roles of the public sector and community in river preservation in Banjarmasin (A case study of the Kuin River, Banjarmasin, South Kalimantan–Indonesia). Sustain Cities Soc. 2018;43:11–20. https://doi.org/10.1016/j.scs.2018.08.004
Lynch AJ, Cooke SJ, Deines AM, et al. The social, economic, and environmental importance of inland fish and fisheries. J Physiol Pharmacol. 2016;24(2):115–121. https://doi.org/10.1139/er-2015-0064
Ngugi CC, Oyoo-Okoth E, Manyala JO, Fitzsimmons K, Kimotho A. Characterization of the nutritional quality of amaranth leaf protein concentrates and suitability of fish meal replacement in Nile tilapia feeds. Aquac Rep. 2017;5:62–69. https://doi.org/10.1016/j.aqrep.2017.01.003
Limburg KE, Hughes RM, Jackson DC, Czech B. Human population increase, economic growth, and fish conservation: collision course or savvy stewardship? Fisheries. 2011;36(1):27–35. https://doi.org/10.1577/03632415.2011.10389053
You SH, Wang SL, Pan WH, Chan WC, Fan AM, Lin P. Risk assessment of methylmercury based on internal exposure and fish and seafood consumption estimates in Taiwanese children. Int J Hygiene Environ Health. 2018;221(4):697–703. https://doi.org/10.1016/j.ijheh.2018.03.002
Varol M, Kaya GK, Alp A. Heavy metal and arsenic concentrations in rainbow trout (Oncorhynchus mykiss) farmed in a dam reservoir on the Firat (Euphrates) River: Risk-based consumption advisories. Sci Total Environ. 2017;599-600:1288–1296. https://doi.org/10.1016/j.scitotenv.2017.05.052
Joardar SN, Abraham TJ, Mandal N. Indian major carp cirrhinus mrigala (hamilton, 1822) inoculated with live aeromonas hydrophila shows dynamic changes in specific immune-cellular activities. J Immunol Immunopathol. 2015;17(1):25–30. https://doi.org/10.5958/0973-9149.2015.00003.9
Ullah S, Hasan Z, Zuberi A. Heavy metals in three commercially valuable cyprinids in the river Panjkora, district Lower Dir, Khyber Pakhtunkhwa, Pakistan. Toxicol Environ Chem. 2016;98(1):64–76. https://doi.org/10.1080/02772248.2015.1100916
Dixit R, Wasiullah X, Malaviya D, et al. Bioremediation of heavy metals from soil and aquatic environment: an overview of principles and criteria of fundamental processes. Sustainability. 2015;7(2):2189–2212. https://doi.org/10.3390/su7022189
Al-Asgah NA, Abdel-Warith AW, Younis ES, Allam HY. Haematological and biochemical parameters and tissue accumulations of cadmium in Oreochromis niloticus exposed to various concentrations of cadmium chloride. Saudi J Biol Sci. 2015;22(5):543–550. https://doi.org/10.1016/j.sjbs.2015.01.002
Liu Y, Chen Q, Li Y, Bi L, Jin L, Peng R. Toxic effects of cadmium on fish. Toxics. 2022;10(10):e622. https://doi.org/10.3390/toxics10100622
Rehman T, Naz S, Hussain R, et al. Exposure to heavy metals causes histopathological changes and alters antioxidant enzymes in fresh water fish (Oreochromis niloticus). Asian J Agricul Biol. 2020;2001(1):1–11. https://doi.org/10.35495/ajab.2020.03.143
Garcia-Vazquez E, Perez J, Martinez JL, et al. High level of mislabeling in Spanish and Greek hake markets suggests the fraudulent introduction of African species. J Agricul Food Chem. 2011;59(2):475–480. https://doi.org/10.1021/jf103754r
Kumar M, Prabhahar C. Physico-chemical parameters of river water: a review. Int J Pharma Biol Arch. 2012;3:1304–1312.
Parthipan P, Muniyan M. Effect of heavy metal nickel on hematological parameters of fresh water fish, Cirrhinus mrigala. J Environ Current Life Sci. 2013;1:46–55.
Khabbazi M, Harsij M, Hedayati SA, Gerami MH, Ghafari-Farsani H. Histopathology of rainbow trout gills after exposure to copper. Iran Soc Ichthyol. 2014;1(3):191–196.
Kamaruzzaman BY, Ong MC, Rina SZ, Joseph B. Levels of some heavy metals in fishes from Pahang river estuary, Pahang, Malaysia. J Biol Sci. 2010;10(2):157–161.
Sabullah MK, Sulaiman MR, Shukor MY, et al. The assessment of cholinesterase from the liver of Puntius javanicus as detection of metal ions. Sci World J. 2014;2014:e571094. https://doi.org/10.1155/2014/571094
Bibi S, Naz S, Saeed S, Chatha AM. A review on histopathological alterations induced by Heavy Metals (Cd, Ni, Cr, Hg) in different fish species. Punjab Univ J Zool. 2021;36(1):81–89. https://dx.doi.org/10.17582/journal.pujz/2021.36.1.81.89
Katoch S, Patial V, Zebrafish: an emerging model system to study liver diseases and related drug discovery. J Appl Toxicol. 2021;41(1):33–51. https://doi.org/10.1002/jat.4031
Yang L, Hu W, Chang Z, et al. Electrochemical recovery and high value-added reutilization of heavy metal ions from wastewater: Recent advances and future trends. Environ Int. 2021;152:e106512. https://doi.org/10.1016/j.envint.2021.106512
Zhang J, Meng H, Kong X, et al. Combined effects of polyethylene and organic contaminant on zebrafish (Danio rerio): Accumulation of 9-Nitroanthracene, biomarkers and intestinal microbiota. Environ Pollut. 2021;277:e116767. https://doi.org/10.1016/j.envpol.2021.116767
Zhang H, Cao H, Meng Y, et al. The toxicity of cadmium (Cd2+) towards embryos and pro-larva of soldatov's catfish (Silurus soldatovi). Ecotoxicol Environ Saf. 2012;80:258–265. https://doi.org/10.1016/j.ecoenv.2012.03.013
Jezierska B, Ługowska K, Witeska M. The effects of heavy metals on embryonic development of fish (a review). Fish Physiol Biochem. 2009;35:625–640. https://doi.org/10.1007/s10695-008-9284-4
Taslima K, Al-Emran M, Rahman MS, et al. Impacts of heavy metals on early development, growth and reproduction of fish–A review. Toxicol Rep. 2022:9:858–868. https://doi.org/10.1016/j.toxrep.2022.04.013
Gouva E, Nathanailides C, Skoufos I, Paschos I, Athanassopoulou F, Pappas IS. Comparative study of the effects of heavy metals on embryonic development of zebrafish. Aquacul Res. 2020;51(8):3255–3267. https://doi.org/10.1111/are.14660
Naeem M, Salam A, Tahir SS, Rauf N. The effect of fish size and condition on the contents of twelve essential and non essential elements in Aristichthys nobilis. Pak Veter J. 2011;31(2):109–112.
Naz S, Javed M. Growth responses of fish during chronic exposure of metal mixture under laboratory conditions. Pak Veter J. 2013;33(3):354–357.
Al-Saeed FA, Naz S, Saeed MH, et al. Oxidative Stress, antioxidant enzymes, genotoxicity and histopathological profile in oreochromis niloticus exposed to lufenuron. Pak Veter J. 2023;43(1):160–166.
Naz S, Javed M, Hayat S, Abdullah S, Bilal M, Shaukat T. Long term effects of lead (Pb) toxicity on the growth performance, nitrogen conversion ratio and yield of major carps. Pak J Agricul Sci. 2008;45(3):53–57.
Naz S, Javed M, Tahir A, Azmat H. Impact of physico-chemical variables of test media on growth performance of metal stressed major carps. Pak J Zool. 2012;44(5):1291–1296.
Naz S, Mansouri B, Chatha AM. et al. Water quality and health risk assessment of trace elements in surface water at Punjnad Headworks, Punjab, Pakistan. Environ Sci Pollut Res. 2022;29(40):61457–61469. https://doi.org/10.1007/s11356-022-20210-4
Qasem NA, Mohammed RH, Lawal DU. Removal of heavy metal ions from wastewater: a comprehensive and critical review. NPJ Clean Water. 2021;4:e36. https://doi.org/10.1038/s41545-021-00127-0
Naz S, Hussain R, Ullah Q, Chatha AM, Shaheen A, Khan RU. Toxic effect of some heavy metals on hematology and histopathology of major carp (Catla catla). Environ Sci Pollut Res. 2021;28(6):6533–6539. https://doi.org/10.1007/s11356-020-10980-0
Zhang Q, Hou Q, Huang G, Fan Q. Removal of heavy metals in aquatic environment by graphene oxide composites: a review. Environ Sci Pollut Res. 2020;27:190-209. https://doi.org/10.1007/s11356-019-06683-w
Li M, Kuang S, Kang Y, Ma H, Dong J, Guo Z. Recent advances in application of iron-manganese oxide nanomaterials for removal of heavy metals in the aquatic environment. Sci Total Environ. 2022;819:e153157. https://doi.org/10.1016/j.scitotenv.2022.153157
Chatha AM, Naz S, Naz S, Khan RU, Nawaz A. heavy metal pollution in water from anthropogenic and natural activities and the remediation strategies. In: Ahmad MI, Mahamood M, Javed M, Alhewairini SS, eds., Toxicology and Human Health: Environmental Exposures and Biomarkers. Singapore: Springer; 2023:27–53. https://doi.org/10.1007/978-981-99-2193-5_2
Zeb BS, Malik AH, Waseem A, Mahmood Q. Water quality assessment of Siffran river, Pakistan. Inter J Phy Sci. 2011;6(34):7789–7798. https://doi.org/10.5897/IJPS11.1385
Chatha AM, Naz S, Mansouri B, Nawaz A. Accumulation and human health risk assessment of trace elements in two fish species, Cirrhinus mrigala and Oreochromis niloticus, at Tarukri Drain, District Rahimyar Khan, Punjab, Pakistan. Environ Sci Pollut Res. 2023;30:56522–56533. https://doi.org/10.1007/s11356-023-26337-2
Ali H, Khan E, Nasir MJ. Bioaccumulation of some potentially toxic heavy metals in freshwater fish of river Shah Alam, Khyber Pakhtunkhwa, Pakistan. Pak J Zool. 2020;52(2):603–608.
Kaya H, Akbulut M, Çelik EŞ, Yılmaz S. Impacts of sublethal lead exposure on the hemato-immunological parameters in tilapia (Oreochromis mossambicus). Toxicol Environ Chem. 2013;95(9):1554–1564. https://doi.org/10.1080/02772248.2014.895363
Rauf A, Javed M, Ubaidullah M. Heavy metal levels in three major carps (catla catla, labeo rohita and cirrhina mrigala) from the river ravi, Pakistan. PakVeter J. 2009;29(1):24–26.
Akan JC, Mohmoud S, Yikala BS, Ogugbuaja VO. Bioaccumulation of some heavy metals in fish samples from river benue in vinikilang, adamawa state, Nigeria. Am J Analyt Chem. 2012;3:727–736. https://doi.org/10.4236/ajac.2012.311097
El-Shafei HM. Some heavy metals concentration in water, muscles and gills of tilapia niloticus as biological indicator of Manzala Lake pollution. J Aquacul Res Develop. 2015;6(9):2–5.
Ahmed MK, Baki MA, Islam MS, et al. Human health risk assessment of heavy metals in tropical fish and shellfish collected from the river Buriganga, Bangladesh. Environ Sci Pollut Res. 2015;22:15880–15890. https://doi.org/10.1007/s11356-015-4813-z
Hussain B, Sultana T, Sultana S, et al. First report on fish cysteine as a biomarker of contamination in the River Chenab, Pakistan. Environ Sci Pollut Res. 2016;23(15):15495–15503. https://doi.org/10.1007/s11356-016-6711-4
Mulk S, Korai AL, Azizullah A, Shahi L, Khattak MN. Marble industry effluents cause an increased bioaccumulation of heavy metals in Mahaseer (Tor putitora) in Barandu River, district Buner, Pakistan. Environ Sci Pollut Res Int. 2017;24(29):23039–23056. https://doi.org/10.1007/s11356-017-9921-5
Azizullah A, Khattak MN, Richter P, Häder DP. Water pollution in Pakistan and its impact on public health—a review. Environ Int. 2011;37(2):479–497. https://doi.org/10.1016/j.envint.2010.10.007
Alam I, Khattak MN, Mulk S, Dawar FU, Shahi L, Ihsanullah I. Heavy metals assessment in water, sediments, algae and two fish species from river Swat, Pakistan. Bull Environ Contamin Toxicol. 2020;105:546–552. https://doi.org/10.1007/s00128-020-02981-z
Khan B, Khan H, Muhammad S, Khan T. Heavy metals concentration trends in three fish species from Shah Alam River (Khyber Pakhtunkhwa Province, Pakistan). J Nat Environ Sci. 2012;3(1):1–8.
Chatta AM, Khan MN, Hadyat I, Ali A, Naqvi SA. Detection of heavy metals (cadmium, led and chromium) in farmed carp fish species, marketed at Lahore, Pakistan: a serious health concern for the consumers. Int J Biosci. 2017;10(4):199–211. http://dx.doi.org/10.12692/ijb/10.4.199-211
Ihtisham-Ur-Rahman IA, Khan A, Ahmad W, et al. Heavy metals (Lead and Cadmium) concentration in different organs of mahseer (Tor putitora) of river Indus at Swabi, KPK, Pakistan. Pure Appl Biol. 2020;9(4):2158–2166. http://dx.doi.org/10.19045/bspab.2020.90230
Yousafzai AM, Khan AR, Shakoori AR. Heavy metal pollution in River Kabul affecting the inhabitant fish population. Pak J Zool. 2008;40(5):331–339.
Khalil A, Jamil A, Khan T. Assessment of heavy metal contamination and human health risk with oxidative stress in fish (Cyprinus carpio) from Shahpur Dam, Fateh Jang, Pakistan. Arab J Geosci. 2020;13:1–10. https://doi.org/10.1007/s12517-020-05933-3
Ali H, Ali W, Ullah K, Akbar F, Khan H. Assessment of Cu and Zn in water, sediments and in the carnivorous fish, Channa gachua from River Swat and River Barandu, Malakand Division, Pakistan. Iran J Sci Technl Transac. 2019;43(1):773–783. https://doi.org/10.1007/s40995-018-0615-8
Shah D, Karibayev M, Adotey EK, Torkmahalleh MA. Impact of volatile organic compounds on chromium containing atmospheric particulate: insights from molecular dynamics simulations. Sci Rep. 2020;10(1):e17387. https://doi.org/10.1038/s41598-020-74522-x
Idrees M. Analysis and human health risk from selected heavy metals in water, sediments and freshwater fish (Labeo Rohia, Cyprinus carpio, glypthothorax Punjabensis) collected from three rivers in district Charsada, Khyber-Pakhtonkhuwa, Pakistan. Carpath J Earth Environ Sci. 2017;12(2):641–648.
Naeem S, Ashraf M, Babar ME, Zahoor S, Ali S. The effects of some heavy metals on some fish species. Environ Sci Pollut Res. 2021;28(20):25566–25578. https://doi.org/10.1007/s11356-021-12385-z
Bano Z, Abdullah S, Ahmad W, Zia MA, Hassan W. Assessment of heavy metals and antioxidant enzyme in different organs of fish from farm, hatchery and Indus river of Pakistan. Pak J Zool. 2017;49(6):2227–2233.
Mohamed AA, El-Houseiny W, Abd Elhakeem EM, Ebraheim LL, Ahmed AI, Abd El-Hakim YM. Effect of hexavalent chromium exposure on the liver and kidney tissues related to the expression of CYP450 and GST genes of Oreochromis niloticus fish: Role of curcumin supplemented diet. Ecotoxicol Environ Saf. 2020;188:e109890. https://doi.org/10.1016/j.ecoenv.2019.109890
Waheed S, Kamal A, Malik RN. Human health risk from organ-specific accumulation of toxic metals and response of antioxidants in edible fish species from Chenab River, Pakistan. Environ Sci Pollut Res. 2014;21:4409–4417. https://doi.org/10.1007/s11356-013-2385-3
Hamid A, Khan MU, Yaqoob J, et al. Assessment of mercury load in river Ravi, urban sewage streams of Lahore Pakistan and its impact on the oxidative stress of exposed fish. J Biodivers Environ Sci. 2016;8(4):63–72.
Iqbal A, Tabinda AB, Yasar A, Mahfooz Y. Heavy metal uptake and toxicity in tissues of commercially important freshwater fish (Labeo rohita and Wallago attu) from the Indus River, Pakistan. Pol J Environ Stud. 2017;26(3):627–633. https://doi.org/10.15244/pjoes/66850
Jabeen F, Chaudhry AS. Monitoring trace metals in different tissues of Cyprinus carpio from the Indus River in Pakistan. Environ Monitor Assess. 2010;170:645–656. https://doi.org/10.1007/s10661-009-1263-4
Yousafzai AM, Ullah F, Bari F, et al. Bioaccumulation of Some Heavy Metals: Analysis and Comparison of Cyprinus carpio and Labeo rohita from Sardaryab, Khyber Pakhtunkhwa. BioMed Res Int. 2017;2017:e5801432. https://doi.org/10.1155/2017/5801432
Munir MA, Khan B, Mian IA, et al. Assessment of Hg accumulation in fish and scalp hair in fishing communities along river Swat, Pakistan. Environ Sci Pollut Res. 2021;28:67159–67166. https://doi.org/10.1007/s11356-021-15348-6
Ahmed Q, Bat L, Öztekin A, Ali QM, Ghory FS, Yousuf F. Metals levels in Sarda orientalis collected from the commercial landings of Karachi Fish Harbor, Pakistan (northern Arabian Sea) and assessment of likely health risks to the consumers. Int J Rapid Commun. 2023;56(2):73–84. https://doi.org/10.1080/00387010.2023.2165506
Chatha AMM, Naz S, Mansouri B, Nawaz A. Accumulation and human health risk assessment of trace elements in two fish species, Cirrhinus mrigala and Oreochromis niloticus, at Tarukri Drain, District Rahimyar Khan, Punjab, Pakistan. Environ Sci Pollut Res. 2023;30:56522–56533. https://doi.org/10.1007/s11356-023-26337-2
Saeed F, Iqbal KJ, Atique U, et al. Toxic trace metals assessment in selected organs of edible fish species, sediment and water in Head Punjnad, Punjab, Pakistan. Punjab Univ J Zool. 2020;35(1):43–50. https://dx.doi.org/10.17582/journal.pujz/2020.35.1.43.50
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