Synthesis, Characterization and Biological Activity of Fe(II), Cu(II), and Cd(II) with Schiff Base Ligands (SBLs): Biological Screening of Divalent Metal Chelated Complex

  • Muhammad Aslam Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
  • Khadija Noor Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
  • Mehreen Lateef Multidisciplinary Research Laboratory, Bahria University Medical and Dental College, Karachi, Pakistan
  • Zahra Noreen Multidisciplinary Research Laboratory, Bahria University Medical and Dental College, Karachi, Pakistan
  • Muhammad Aneeq Javed Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
  • Mehvish Abdul-Rehman Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
  • Khansa Habibullah Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
  • Aamir Sohail Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
Keywords: azomethine group, chelation, metal complex, Schiff base ligands (SBLs), transition metal ion

Abstract

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This study aimed to develop novel Schiff base ligands (SBLs), namely N1,N2-Bis(4-nitrobenzylidene)benzene-1,2-diamine (1), 4,6-Dimethyl-N-((5-nitrofuran-2-yl)methylene)pyrimidin-2-amine (2) and N1,N2-Bis((5-nitrofuran-2-yl)methylene)benzene-1,2-diamine (3). It also aimed to examine how they coordinate with various bidentate transition metal ions to form metal complexes. The goal was to properly characterize the newly synthesized chemicals and investigate their possible uses in chemical and pharmaceutical industries, with an emphasis on the drug industry. Thin-layer chromatography (TLC) was used to methodically monitor and confirm the synthesis process at each step. The compounds were then put through characterization procedures such as Fourier transform infrared spectroscopy (FTIR), urease inhibition assays, and assessments of antioxidant activity.

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Published
2024-07-04
How to Cite
1.
Aslam M, Noor K, Mehreen Lateef, Zahra Noreen, Javed MA, Abdul-Rehman M, Habibullah K, Sohail A. Synthesis, Characterization and Biological Activity of Fe(II), Cu(II), and Cd(II) with Schiff Base Ligands (SBLs): Biological Screening of Divalent Metal Chelated Complex. Sci Inquiry Rev. [Internet]. 2024Jul.4 [cited 2024Jul.16];8(2):51-3. Available from: https://journals.umt.edu.pk/index.php/SIR/article/view/4699
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