Phytochemistry of Ziziphus Mauritiana; its Nutritional and Pharmaceutical Potential

  • Shumaila Zulfiqar Butt Department of Chemistry, Lahore Garrison University, DHA Phase VI, Lahore, Pakistan
  • Shabbir Hussain Department of Chemistry, Lahore Garrison University, Lahore, Pakistan
  • Khurram Shahzad Munawar Department of Chemistry, University of Mianwali 42200, Mianwali, Pakistan
  • Affifa Tajammal Department of Chemistry, Lahore Garrison University, Lahore, Pakistan
  • Muazzam Ali Muazzam Department of Chemistry, Lahore Garrison University, Lahore, Pakistan
Keywords: Nutritional, Pharmaceutical, Phytochemicals, Ziziphus Mauritiana, Ber

Abstract

Abstract Views: 871

Current studies were performed to overview the phytochemistry, nutritional and medicinal value of Ziziphus mauritiana (commonly known as Ber in Pakistan). The leaves of Z. mauritiana are comprised of proteins, amino acids, alkaloids, terpenoids, fibers, flavonoids, tannins, glycosides, and phenolic compounds. The leave majorly demonstrate the presence of α-linolenic acid, plamitic acid and methyl stearate in n-hexane, chloroform and methanol extracts. The seed contains the highest content of carbohydrate (63.24%) and calorific value (411.61 kJ) while its fruit shows the highest quantity of moisture. Its fruit is slightly acidic (pH around 4.77) and rich in nutrients including proteins, carbohydrates vitamin C and minerals (Fe, Zn, Cu, Na, K, Ca, P). The fruit provides energy of 1516-1575 kJ per its 100 g. Z. mauritiana displays antibacterial, antioxidant and anti-inflammatory activities. Its leaves are used for treating tuberculosis, small pox, burning sensations, dysentary asthma, fever, liver issues, infections and blood relating diseases. Root bark of this plant shows good effectiveness as analgesic, anti-inflammatory and anti-allergic agent. The plant displays strong antioxidant potential and excellent H2O2 scavenging activities.

Copyright (c) The Authors

Downloads

Download data is not yet available.

References

. Naseer S, Hussain S, Zahid Z. Nutritional and antioxidant potential of common

vegetables in Pakistan. RADS J Biol Res Appl Sci. 2019;10(1):36-40. https://doi.org/10.37962/jbas.v10i1.146

. Kamran M, Hussain S, Abid MA, et al. Phytochemical composition of moringa oleifera its nutritional and pharmacological importance. Postepy Biol Komorki. 2020;47(3):321-34.

. Rehman A, Hussain S, Javed M, et al. Chemical composition and remedial perspectives of Hippophae rhamnoides linn. Postepy Biol Komorki. 2018;45(3):199-209.

. Farhat N, Hussain S, Syed SK, et al. Dietary phenolic compounds in plants: Their antioxidant and pharmacological potential. Postepy Biol Komorki. 2020;47(3):307-20.

. Kumar M, Puri S, Pundir A, et al. Evaluation of Nutritional, Phytochemical, and Mineral Composition of Selected Medicinal Plants for Therapeutic Uses from Cold Desert of Western Himalaya Plants. 2021;10(7):1429. https://doi.org/10.3390/plants10071429

. Rehman A, Adnan M. Nutritional potential of Pakistani medicinal plants and their contribution to human health in times of climate change and food insecurity. Pak J Bot. 2018;50(1):287-300.

. Petrovska BB. Historical review of medicinal plants’ usage. Pharmacogn. Rev. 2012;6(11):1-5. https://doi.org/10.4103/0973-7847.95849

. Najafi S, Sanadgol N, Nejad BS, Beiragi MA, Sanadgol E. Phytochemical screening and antibacterial activity of Citrullus colocynthis (Linn.) Schrad against Staphylococcus aureus. J Med Plant Res. 2010;4(22):2321-5. https://doi.org/10.5897/JMPR10.192

. Ashraf A, Sarfraz RA, Anwar F, Shahid SA, Alkharfy KM. Chemical composition and biological activities of leaves of Ziziphus mauritiana L. native to Pakistan. Pak J Bot. 2015;47(1):367-76.

. Goyal M, Nagori BP, Sasmal D. Review on ethnomedicinal uses, pharmacological activity and phytochemical constituents of Ziziphus mauritiana (Z. jujuba Lam., non Mill). Spatula DD. 2012;2(2):107-16.

. Dahiru D, Sini J, John-Africa L. Antidiarrhoeal activity of Ziziphus mauritiana root extract in rodents. Afr J Biotechnol. 2006;5(10):941-945.

. Pareek OP. Fruits for the Future 2: Ber, International Centre for Underutilized Crop. Redwood Books, Wiltshire. 2001;38:15-20.

. Naseer S, Afzal M, Nisa A, et al. Extraction of brown dye from Eucalyptus bark and its applications in food storage. Qual Assur Saf Crops Foods. 2019;11(8):769-80.

. Naseer S, Hussain S, Naeem N, Pervaiz M, Rahman M. The phytochemistry and medicinal value of Psidium guajava (guava). Clin Phytoscience. 2018;4(1):1-8. https://doi.org/10.1186/s40816-018-0093-8

. Riaz S, Hussain S, Syed SK, Anwar R. Chemical Characteristics and Therapeutic Potentials of Aloe vera. RADS J Biol Res Appl Sci. 2021;12(1):1-7. https://doi.org/10.37962/jbas.v12i1.279

. Gupta M, Bhandari A, Singh RK. Pharmacognostical evaluations of the leaves of Ziziphus mauritiana. Int J Pharm Sci Res. 2012;3(81):818-821.

. Guo S, Duan J, Zhao J, Qian D, Zhang W. Chemical constituents from seeds of Ziziphus mauritiana. Zhong yao cai. 2014;37(3):432-5.

. Maruza I, Musemwa L, Mapurazi S, Matsika P, Munyati V, Ndhleve S. Future prospects of Ziziphus mauritiana in alleviating household food insecurity and illnesses in arid and semi-arid areas: a review. World Dev Perspect. 2017;5:1-6. https://doi.org/10.1016/j.wdp.2017.01.001

. Mbahi M, Mbahi A, Umar I, Ameh D, Joseph I. Phytochemical screening and antimicrobial activity of the pulp extract and fractions of ziziphus mauritiana. Biochem Anal Biochem. 2018;7:1000352. https://doi.org/10.4172/2161-1009.1000352

. Najafi S. Phytochemical screening and antibacterial activity of leaf extract of Ziziphus mauritiana Lam. Int Res J Basic Appl Sci. 2013;4(10):3274-6.

. Mohd Jailani FNA, Zaidan UH, Hanizam Abdul Rahim MB, Abd Gani SS, Halmi MIE. Evaluation of constituents and physicochemical properties of Malaysian underutilized Ziziphus mauritiana (Bidara) for nutraceutical potential. Int J Fruit Sci. 2020;20(3):394-402. https://doi.org/10.1080/15538362.2019.1641458

. Bakhshi J, Singh P. Ber: a good choice for semi-arid and marginal soils. Indian J Hortic. 1974:27-30.

. Yerima B, Adamu H. Proximate chemical analysis of nutritive contents of jujube (Ziziphus mauritiana) seeds. Phys Sci Int J. 2011;6(36):8079-82.

. Nyanga LK, Gadaga TH, Nout MJ, Smid EJ, Boekhout T, Zwietering MH. Nutritive value of masau (Ziziphus mauritiana) fruits from Zambezi Valley in Zimbabwe. Food Chem. 2013;138(1):168-72.

. Bal J, JS B, SS M. Ascorbic Acid Content of Ber During Growth and Maturity. 1978:238-239.

. Tiwari R, Banafar R. Studies on the nutritive constituents yield and yield attributing characters in some ber (Zizyphus jujuba) genotypes. Indian J Plant Physiol. 1995;38:88-9.

. Al-Saeedi AH, Al-Ghafri MTH, Hossain MA. Brine shrimp toxicity of various polarities leaves and fruits crude fractions of Ziziphus jujuba native to Oman and their antimicrobial potency. Sustain Chem Pharm. 2017;5:122-6. https://doi.org/10.1016/j.scp.2017.03.003

. Agarwal SK, Singh SS, Verma S, Kumar S. Two new aliphatic compounds from the leaves of Ziziphus mauritiana. Ind J Chem Sec B: Org Chem Incl Med Chem. 2000;39:872-4.

. Peng W-H, Hsieh M-T, Lee Y-S, Lin Y-C, Liao J. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. J Ethnopharmacol. 2000;72(3):435-41. https://doi.org/10.1016/S0378-8741(00)00255-5

. Oudhia P. Medicinal Herbs of Chhattisgarh, India Having Less Known Traditional Uses 64. Peela Gulmohar (Peltophorum pterocarpum, family: Ceasalpi niaceae). Research Note. 2003;395.

. Adzu B, Amos S, Wambebe C, Gamaniel K. Antinociceptive activity of Zizyphus spina-christi root bark extract. Fitoterapia. 2001;72(4):344-50. https://doi.org/10.1016/S0367-326X(00)00289-6

. Dutta RP, Patil MB. Therapeutic potential of root and stem bark of wild medicinal plant Ziziphus mauritiana (Lamk.) against silica induced toxicity in Wistar albino rats. J Ethnopharmacol. 2018;224:111-8. https://doi.org/10.1016/j.jep.2018.04.045

. Michel A. Tree, shrub and liana of West African zone. Margraf Publishers GMBH, Paris; 2002.

. Deshpande MS, Tondare PR, Paygude SV, Apte KG, Parab PB. Evaluation of antioxidant, anti-inflammatory and adipocyte differentiation inhibitory potential of Ziziphus mauritiana bark extract. J Pharmacognosy. 2013;5(5):205-10. https://doi.org/10.1016/j.phcgj.2013.08.005

. Nakayama T, Suzuki S, Kudo H, Sassa S, Nomura M, Sakamoto S. Effects of three Chinese herbal medicines on plasma and liver lipids in mice fed a high-fat diet. J Ethnopharmacol. 2007;109(2):236-40. https://doi.org/10.1016/j.jep.2006.07.041

. Pisha E, Chai H, Lee I-S, et al. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med. 1995;1(10):1046-51. https://doi.org/10.1038/nm1095-1046

. Kumar S, Ganachari M, Nagoor V. Anti-inflammatory activity of Ziziphus jujuba Lam leaves extract in rats. J Nat Remedies. 2004;4(2):183-5. https://doi.org/10.18311/jnr/2004/185

. Wang B-N, Liu HF, Zheng JB, Fan MT, Cao W. Distribution of phenolic acids in different tissues of jujube and their antioxidant activity. J Agric Food Chem. 2011;59(4):1288-92. https://doi.org/10.1021/jf103982q

. Li J-w, Ding S-d, Ding X-l. Comparison of antioxidant capacities of extracts from five cultivars of Chinese jujube. Process Biochem. 2005;40(11):3607-13. https://doi.org/10.1016/j.procbio.2005.03.005

. Li J-W, Fan L-P, Ding S-D, Ding X-L. Nutritional composition of five cultivars of Chinese jujube. Food Chem. 2007;103(2):454-60. https://doi.org/10.1016/j.foodchem.2006.08.016

. Gao Q-H, Wu P-T, Liu J-R, Wu C-S, Parry JW, Wang M. Physico-chemical properties and antioxidant capacity of different jujube (Ziziphus jujuba Mill.) cultivars grown in loess plateau of China. Sci Hortic. 2011;130(1):67-72. https://doi.org/10.1016/j.scienta.2011.06.005

. Patel PR, Rao TVR. Physiological changes in relation to growth and ripening of khirni [Manilkara hexandra (Roxb.) Dubard] fruit. Fruits. 2009;64(3):139-46. https://doi.org/10.1051/fruits/2009009

. Sivasankari M, Sankaravadivoo A. Studies on antimicrobial activity of ZIZIPHUS mauritiana LAM. Int J Ayurveda Pharma Res. 2015;3(7):1-4.

. Dahiru D, Obidoa O. Evaluation of the antioxidant effects of Ziziphus mauritiana lam. leaf extracts against chronic ethanol-induced hepatotoxicity in rat liver. Afr. J. Tradit. Complement. Altern Med. 2008;5(1):39-45. https://doi.org/10.4314/ajtcam.v5i1.31254

. Tringali C. Identification of bioactive metabolites from the bark of Pericopsis (Afrormosia) laxiflora. Phytochem Anal. 1995;6(6):289-91. https://doi.org/10.1002/pca.2800060603

. Bhatia A, Mishra T. Hypoglycemic activity of Ziziphus mauritiana aqueous ethanol seed extract in alloxan-induced diabetic mice. Pharm Biol. 2010;48(6):604-10. https://doi.org/10.3109/13880200903218935

. Dahiru D, William E, Nadro M. Protective effect of Ziziphus mauritiana leaf extract on carbon tetrachloride-induced liver injury. Afr J Biotechnol. 2005;4(10):1177-1179.

. Yu F, De Luca V. ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus. Proc Natl Acad Sci. 2013;110(39):15830-5. https://doi.org/10.1073/pnas.1307504110

. Gupta VK, Sharma SK. Plants as natural antioxidants. 2006:326-334. http://hdl.handle.net/123456789/7962

. Maxwell SR. Prospects for the use of antioxidant therapies. Drugs. 1995;49(3):345-61. https://doi.org/10.2165/00003495-199549030-00003

. Dalleau S, Baradat M, Gueraud F, Huc L. Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance. Cell death and differentiation. 2013;20(12):1615-1630. https://doi.org/10.1038/cdd.2013.138

. Mahmoudian M, Jalipour H, Salehian Dardashti P. Toxicity of peganum harmala: review and a case report. Iran J Pharmacol. 2002;1(1):1-10.

. Olajuyigbe OO, Afolayan AJ. Phenolic content and antioxidant property of the bark extracts of Ziziphus mucronata Willd. subsp. mucronata Willd. BMC Complement Altern Med 2011;11(1):130. https://doi.org/10.1186/1472-6882-11-130

. Afroz R, Tanvir E, Islam MA, Alam F, Gan SH, Khalil MI. Potential Antioxidant and Antibacterial Properties of a Popular Jujube Fruit: A pple Kul (Z izyphus mauritiana). J. Food Biochem. 2014;38(6):592-601. https://doi.org/10.1111/jfbc.12100

. Al Ghasham A, Al Muzaini M, Qureshi KA, et al. Phytochemical screening, antioxidant and antimicrobial activities of methanolic extract of Ziziphus mauritiana Lam. Leaves Collected from Unaizah, Saudi Arabia

Int J Pharm Res Allied Sci. 2017;6(3):33-46.

. Memon AA, Memon N, Bhanger MI, Luthria DL. Assay of phenolic compounds from four species of ber (Ziziphus mauritiana L.) fruits: comparison of three base hydrolysis procedure for quantification of total phenolic acids. Food Chem. 2013;139(1-4):496-502. https://doi.org/10.1016/j.foodchem.2013.01.065

. Shahidi F, Naczk M. An overview of the phenolics of canola and rapeseed: chemical, sensory and nutritional significance.

J Am Oil Chem Soc. 1992;69(9):917-24. https://doi.org/10.1007/BF02636344

. Mishra T, Khullar M, Bhatia A. Anticancer potential of aqueous ethanol seed extract of Ziziphus mauritiana against cancer cell lines and Ehrlich ascites carcinoma. Evid.-Based Complementary Altern. Med. 2011;2011:1-12. https://doi.org/10.1155/2011/765029

Published
2021-06-11
How to Cite
1.
Butt SZ, Hussain S, Khurram Shahzad Munawar, Tajammal A, Muazzam MA. Phytochemistry of Ziziphus Mauritiana; its Nutritional and Pharmaceutical Potential. Sci Inquiry Rev. [Internet]. 2021Jun.11 [cited 2024Aug.29];5(2):1-15. Available from: https://journals.umt.edu.pk/index.php/SIR/article/view/1405
Section
Orignal Article