Prevalence of Dyslipidemia in Apparently Healthy Population of Dera Ismail Khan, Pakistan
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Dyslipidemia and its high prevalence in patients with hypertension and other non-communicable diseases is increasing day by day. The current study aimed to highlight the presence of dyslipidemia via lipid profiling in the apparently healthy population of Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan. This study recruited 150 individuals who were apparently healthy and had no previous records of hyperlipidemia. Blood plasma samples were collected aseptically from healthy individuals to determine their lipid profile. Total cholesterol (TC) level, high density lipoprotein cholesterol (HDL-C) level, triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) level were determined. The age of the 150 healthy subjects ranged between 20-70 years. Mean plasma level of TC was 166.4 ±28.45 mg/dl, HDL-C was 48.34 ±8.79 mg/dl, 48.34 ±8.79 mg/dl, LDL-C was 87.42 ±29.82 mg/dl, and TG were 151 ±65.92 mg/dl. TC and HDL-C levels were in the appropriate range. LDL-C level was below 100 mg/dl. The triglyceride (TG) level was recorded above the upper limit. The alarmingly high prevalence of TC in the healthy population may be an indication of underlying health issues. It also reflects their unhealthy dietary pattern and poor lifestyle. Thus, it is recommended that a community based epidemiological survey should be conducted to identify the causes of high total cholesterol (TC), since the resultant data will help authorities devise future plans to curb dyslipidemia and its related complications.
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Kopin L, Lowenstein CJ. Dyslipidemia. Ann Intern Med. 2017;167(11):81-96.
Mahalle N, Garg MK, Naik SS, Kulkarni MV. Study of pattern of dyslipidemia and its correlation with cardiovascular risk factors in patients with proven coronary artery disease. Indian J Endocrinol Metab. 2014;18(1):48-55. https://doi.org/110.4103/2230-8210.139238
Enas EA, Chacko V, Pazhoor SG, Chennikkara H, Devarapalli HP. Dyslipidemia in south Asian patients. Curr Atheroscler Rep. 2007;9(5):367-74.
Sher K, Shah S, Kumar S. Etiologic patterns of ischaemic stroke in young adults. J Coll Phys Surg Pak. 2013;23(7):472-5.
Khealani BA, Hameed B, Mapari UU. Stroke in Pakistan. J Pak Med Assoc. 2008;58(7):400-409.
Saeed A, Virani SS, Mulukutla S, Chow CK. Dyslipidemia and cardiovascular disease prevention in south asians: a review and discussion of causes, challenges and management strategies. Curr Diabet Rev. 2021;17(9):e011221190238.
Ardeshna DR, Bob-Manuel T, Nanda A, et al. Asian-Indians: a review of coronary artery disease in this understudied cohort in the United States. Ann Transl Med. 2018;6(1):1-12. https://doi.org/110.21037/atm.2017.10.18
Wang M, Liu M, Li F, et al. Gender heterogeneity in dyslipidemia prevalence, trends with age and associated factors in middle age rural Chinese. Lipid Health Dis. 2020;19(1):1-1. https://doi.org/10.1186/s12944-020-01313-8
Rajagopal G, Suresh V, Sachan A. High-density lipoprotein cholesterol: How High. Indian J. Endocrinoland Met. 2012;16(Suppl 2):1-11. https://doi.org/10.32350/sir.51.05
Pongchaiyakul C, Hongsprabhas P, Pisprasert V, Pongchaiyakul C. Rural-urban difference in lipid levels and prevalence of dyslipidemia: a population-based study in Khon Kaen province, Thailand. J Med Assoc Thai. 2006;89(11):1835.
Tarar OM, Ahmed KM, Nishtar NA, et al. Understanding the complexities of prevalence of trans fat and its control in food supply in Pakistan. J Clin Hypertens. 2020 Aug;22(8):1338-46. https://doi.org/10.1111/jch.13943
Rahim S. To Study the Relationship of HDLc (Cholesterol) & Myocardial Infarction. Opthamology Update Vol. 15 No. 3, July-September 2017 ii.:265.
Basit A, Sabir S, Riaz M, Fawwad A. NDSP 05: Prevalence and pattern of dyslipidemia in urban and rural areas of Pakistan; a sub analysis from second National Diabetes Survey of Pakistan (NDSP) 2016–2017. JDiabetes Met Disord. 2020;19(2):1215-25. https://doi.org/10.1007/s40200-020-00631-z
Shahid SU, Sarwar S. The abnormal lipid profile in obesity and coronary heart disease (CHD) in Pakistani subjects. Lipids Health Dis. 2020;19(1):1-7. https://doi.org/10.1186/s12944-020-01248-0
Iqbal W, Inayat A, Faisal MS, Hayat W, Khalil KU. Frequency of dyslipidaemia in patients with essential hypertension; a cross sectional study done in tertiary care hospital of Peshawar. J Med Sci. 2019 Mar 29;27(1):34-7.
Otsuka T, Takada H, Nishiyama Y, et al. Dyslipidemia and the risk of developing hypertension in a working‐age male population. J Am Heart Assocn. 2016;5(3):e003053. https://doi.org/10.1161/JAHA.115.003053
Safi SZ, Qvist R, Kumar S, Batumalaie K, Ismail IS. Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targets. Biomed Res Int. 2014;2014:801269. https://doi.org/10.1155/2014/801269
Hedayatnia M, Asadi Z, Zare-Feyzabadi R, et al. Dyslipidemia and cardiovascular disease risk among the MASHAD study population. Lipids Health Dis. 2020;19(1):1-1. https://doi.org/10.1186/s12944-020-01204-y
Chang YC, Wu WC. Dyslipidemia and diabetic retinopathy. Rev Diabetic Studies: RDS. 2013;10(2-3):121. https://doi.org/10.1900/RDS.2013.10.121
Chen SC, Tseng CH. Dyslipidemia, kidney disease, and cardiovascular disease in diabetic patients. Rev Diabet Stud: RDS. 2013;10(2-3):88.
Safi SZ, Batumalaie K, Mansor M, et al. Glutamine treatment attenuates hyperglycemia-induced mitochondrial stress and apoptosis in umbilical vein endothelial cells. Clin. 2015;70:569-76. https://doi.org/10.6061/clinics/2015(08)07
Safi SZ, Qvist R, Chinna K, Ashraf MA, Paramasivam D, Ismail IS. Gene expression profiling of the peripheral blood mononuclear cells of offspring of one type 2 diabetic parent. Int J Diabet Develop Count. 2016;36(4):407-19.
Safi SZ, Qvist R, Yan GO, Ismail IS. Differential expression and role of hyperglycemia induced oxidative stress in epigenetic regulation of β1, β2 and β3-adrenergic receptors in retinal endothelial cells. BMC Med Genom. 2014;7(1):1-3. https://doi.org/10.1186/1755-8794-7-29
Makboon K, Phupolpian T, Suklim N. Lipid profile test and factors associated with TC/HDL-C ratio among dyslipidemia population in Muang district, Trang province. J Nursing Public Health. 2019;6(3):69-81.
Wu L, Parhofer KG. Diabetic dyslipidemia. Metabolism. 2014;63(12):1469-79. https://doi.org/10.1016/j.metabol.2014.08.010
Nam KW, Kwon HM, Jeong HY, Park JH, Kwon H, Jeong SM. High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study. Cardiovasc Diabetol. 2020;19(1):1-8. https://doi.org/10.1186/s12933-020-01031-6
Zaid M, Hasnain S. Plasma lipid abnormalities in Pakistani population: trends, associated factors, and clinical implications. Brazilian J Med Bio Res. 2018;51(9):1-9.
Iqbal MP, Shafiq M, Mehboobali N, et al. Hypertriglyceridemia and low HDL-cholesterol are the major lipid abnormalities in normal Pakistani adults: Are these contributing to the high rates of coronary artery disease in this population? Pak J Med Sci. 2004;20(4):385-91.
Aziz J, Siddiqui NA, Siddiqui IA, Omair A. Relation of body mass index with lipid profile and blood pressure in young healthy students at Ziauddin Medical University. J Ayub Med Coll. 2003;15(4):57-9.
Agomuoh DI, Akpa MR, Alasia DD. Lipid profile of healthy adult Nigerians in Port Harcourt, Nigeria. Niger J Med. 2006;15(2):137-40. https://doi.org/10.4314/njm.v15i2.37097
Safi SZ, Badshah Y, Waheed Y, et al. Distribution of hepatitis C virus genotypes, hepatic steatosis and their correlation with clinical and virological factors in Pakistan. Asian Biomed. 2010;4(2):253-62.
Copyright (c) 2021 Nawshad Muhammad, Shamsher Ullah, Sher Zaman Safi
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