Development and Validation of a UV-Spectrophotometric Method for the Estimation of Atorvastatin in Bulk and Tablet Dosage Form
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A new UV-spectrophotometric method is devised that uses methanol as a solvent to precisely measure the quantity of atorvastatin present in both raw materials and pharmaceutical dosage form. It is efficient, accurate, simple, quick, and distinctive. High sensitivity and accuracy are the distinguishing features of this approach. Atorvastatin’s max was located at 247 nm. A linear relationship between the concentrations of 10-20 g ml-1 was discovered, exhibiting a high correlation coefficient. The new method’s precision, linearity, accuracy, and limit of detection (LOD) were all validated statistically. The results affirm the suitability of this method for daily analysis of atorvastatin in both its raw form and pharmaceutical formulations. Furthermore, it is noteworthy that this method avoids the need for costly solvents, extraction procedures, derivatization, and time-consuming steps. Hence, it is successfully applied to pharmaceutical formulations and validated in harmony with the standard procedures of the International Council of Harmonization (ICH)
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