Evaluating Frontiers in Nanotechnology: A Review of Novel Nanoparticle Technology in Drug Delivery Systems (DDS)

  • Zainab Naeem Department of Pharmacy, University of Central Punjab, Lahore, Pakistan
  • Tayyaba Rana Department of Pharmacy, University of Central Punjab, Lahore, Pakistan https://orcid.org/0000-0003-4338-1651
  • Sumiyya Javaid Department of Pharmacy, University of Central Punjab, Lahore, Pakistan
Keywords: applications of nanoparticles, drug therapy, diagnostics, Drug Delivery Systems (DDS), nanoparticles, nanotechnology

Abstract

Abstract Views: 427

Nanotechnology is a groundbreaking field that manipulates materials at the nanoscale, enabling unprecedented control over their properties. In medicine, nanoparticles enable targeted drug delivery and precise diagnostics. In electronics, they contribute to miniaturized devices and high-performance sensors. Additionally, nanoparticles also encompass their role in environmental remediation techniques. The current review article aims to provide a comprehensive and updated overview of recent developments in nanotechnology by highlighting the key advancements, novel applications, and future directions. Moreover, this article also contributes to the current understanding and impact of nanotechnology on multiple sectors by providing valuable insights for future researchers. For this purpose, different preparation methods can be used to prepare nanoparticles and offer various advantages due to their varying size, as they can cross the blood- brain barrier and skin, they are used in cosmetics, and they have many applications in drug therapy and diagnostics.

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References

Jeevanandam J, Barhoum A, Chan YS, Dufresne A, Danquah MK. Review on nanoparticles and nanostructured materials: History, sources, toxicity and regulations. Beilstein J Nanotechnol. 2018;9:1050–1074. https://doi.org/10.3762%2Fbjnano.9.98

Khan I, Saeed K, Khan I. Review nanoparticles: Properties, applications and toxicities. Arab J Chem. 2019;12(7):908–931. https://doi.org/10.1016/j.arabjc.2017.05.011

Varan G, Akkın S, Demirtürk N, Benito JM, Bilensoy E. Erlotinib entrapped in cholesterol-depleting cyclodextrin nanoparticles shows improved antitumoral efficacy in 3D spheroid tumors of the lung and the liver. J Drug Target. 2021;29(4):439–453. https://doi.org/10.1080/1061186X.2020.1853743

Caracciolo G, Vali H, Moore A, Mahmoudi M. Challenges in molecular diagnostic research in cancer nanotechnology. Nano Today. 2019;27:6–10. https://doi.org/10.1016/j.nantod.2019.06.001

Prerna DA, Ratan G. Nanoparticles: An overview. Drug Cell Therap Haematol. 2021;10(1):1487–1497.

Yezdani U, Khan MG, Kushwah N, Verma A, Khan F. Nanotechnology in diagnosis and treatment of various diseases and its future advances in medicine. World J Pharm Pharm Sci. 2018;7(11):1611–1633. https://doi.org/10.20959/wjpps201818-12703

Jamkhande PG, Ghule NW, Bamer AH, Kalaskar MG. Metal nanoparticles synthesis: An overview on methods of preparation, advantages and disadvantages, and applications. J Drug Deliv Sci Technol. 2019;53:e101174. https://doi.org/10.1016/j.jddst.2019.101174

Kanelidis I, Kraus T. The role of ligands in coinage-metal nanoparticles for electronics. Beilstein J Nanotechnol. 2017;8:2625–2639. https://doi.org/10.3762/bjnano.8.263

Guo D, Xie G, Luo J. Mechanical properties of nanoparticles: Basics and applications. J Phys D: Appl Phys. 2013;47:e013001. https://doi.org/10.1088/0022-3727/47/1/013001

D’Amato R, Falconieri M, Gagliardi S, et al. Synthesis of ceramic nanoparticles by laser pyrolysis: From research to applications. J Anal Appl Pyrolysis. 2013;104:461–469. https://doi.org/10.1016/j.jaap.2013.05.026

Tiquia-Arashiro S, Rodrigues DF. Extremophiles: Applications in Nanotechnology. Springer; 2016. https://doi.org/10.1007/978-3-319-45215-9

Castro E, Kumar A. Nanoparticles in drug delivery systems. In: Arun K, Mansour HM, Adam F, Eric RB, eds. Nanomedicine in drug delivery. Boca Raton: CRC Press; 2013:1–22.

Tang L, He S, Yin Y, et al. Combination of nanomaterials in cell-based drug delivery systems for cancer treatment. Pharmaceutics. 2021;13(11):e1888. https://doi.org/10.3390/pharmaceutics13111888

Kreuter J. Drug delivery to the central nervous system by polymeric nanoparticles: What do we know? Adv Drug Deliv Rev. 2014;71:2–14. https://doi.org/10.1016/j.addr.2013.08.008

Kulkarni SA, Feng S-S. Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery. Pharm Res. 2013;30:2512–2522. https://doi.org/10.1007/s11095-012-0958-3

Truong NP, Whittaker MR, Mak CW, Davis TP. The importance of nanoparticle shape in cancer drug delivery. Expert Opin Drug Deliv. 2015;12(1):129–142. https://doi.org/10.1517/17425247.2014.950564

Hui Y, Yi X, Hou F, et al. Role of nanoparticle mechanical properties in cancer drug delivery. ACS Nano. 2019;13(7):7410–7424. https://doi.org/10.1021/acsnano.9b03924

SC Thomas, Mishra PK, Talegaonkar S. Ceramic nanoparticles: Fabrication methods and applications in drug delivery. Curr Pharm Des. 2015;21(42):6165–6188.

Vengala P, Dintakurthi S, Subrahmanyam CVS. Lactose coated ceramic nanoparticles for oral drug delivery. J Pharm Res. 2013;7(6):540–545. https://doi.org/10.1016/j.jopr.2013.06.015

Sourice J, Quinsac A, Leconte Y, et al. One-step synthesis of Si@ C nanoparticles by laser pyrolysis: High-capacity anode material for lithium-ion batteries. ACS Appl Mater Interfaces. 2015;7(12):6637–6644. https://doi.org/10.1021/am5089742

Mostafa AM, Mwafy EA. Synthesis of ZnO and Au@ ZnO core/shell nano-catalysts by pulsed laser ablation in different liquid media. J Mater Res Technol. 2020;9(3):3241–3248. https://doi.org/10.1016/j.jmrt.2020.01.071

Wang B, Wang C, Yu X, et al. General synthesis of high-entropy alloy and ceramic nanoparticles in nanoseconds. Nat Synth. 2022;1:138–146. https://doi.org/10.1038/s44160-021-00004-1

Ismik D, Mansuroglu DS, Buluş E, Sahin YM. The use of chitosan nanoparticles obtained by ionic gelation method as a drug delivery system. J Mater Electron Device. 2020;5(1):6–11.

Katouzian I, Jafari SM. Nano-encapsulation as a promising approach for targeted delivery and controlled release of vitamins. Trends Food Sci Technol. 2016;53:34–48. https://doi.org/10.1016/j.tifs.2016.05.002

Zielińska A, Carreiró F, Oliveira AM, et al. Polymeric nanoparticles: Production, characterization, toxicology and ecotoxicology. Molecules. 2020;25(16):e3731. https://doi.org/10.3390/molecules25163731

Majid A, Ahmed W, Patil-Sen Y, Sen T. Synthesis and characterisation of magnetic nanoparticles in medicine. In: Jackson M, Ahmed W, eds. Micro and Nanomanufacturing Volume II. Springer Cham; 2018: 413–442. https://doi.org/10.1007/978-3-319-67132-1_14

Patil YP, Jadhav S. Novel methods for liposome preparation. Chem Phys Lip. 2014;177:8–18. https://doi.org/10.1016/j.chemphyslip.2013.10.011

Allen TM, Cullis PR. Liposomal drug delivery systems: From concept to clinical applications. Adv Drug Deliv Rev. 2013;65(1):36–48. https://doi.org/10.1016/j.addr.2012.09.037

Gabizon AA, Patil Y, La-Beck NM. New insights and evolving role of pegylated liposomal doxorubicin in cancer therapy. Drug Resist Updat. 2016;29:90–106. https://doi.org/10.1016/j.drup.2016.10.003

Bozzuto G, Molinari A. Liposomes as nanomedical devices. Int J Nanomedicine. 2015;10:975–999. https://doi.org/10.2147/IJN.S68861

Daraee H, Etemadi A, Kouhi M, Alimirzalu S, Akbarzadeh A. Application of liposomes in medicine and drug delivery. Artif Cells Nanomed Biotechnol. 2016;44(1):381–391. https://doi.org/10.3109/21691401.2014.953633

Palchetti S, Colapicchioni V, Digiacomo L, et al. The protein corona of circulating PEGylated liposomes. Biochim Biophys Acta Biomembr. 2016;1858(2):189–196. https://doi.org/10.1016/j.bbamem.2015.11.012

Nsairat H, Khater D, Sayed U, Odeh F, Al Bawab A, Alshaer W. Liposomes: structure, composition, types, and clinical applications. Heliyon. 2022;8:e09394. https://doi.org/10.1016/j.heliyon.2022.e09394

Kamiya K, Takeuchi S. Giant liposome formation toward the synthesis of well-defined artificial cells. J Mater Chem B. 2017;5(30):5911–5923. https://doi.org/10.1039/C7TB01322A

Chaurasiya A, Gorajiya A, Panchal K, Katke S, Singh AK. A review on multivesicular liposomes for pharmaceutical applications: Preparation, characterization, and translational challenges. Drug Deliv Transl Res. 2022;12:1569–1587. https://doi.org/10.1007/s13346-021-01060-y

Salimi A. Liposomes as a novel drug delivery system: Fundamental and pharmaceutical application. Asian J Pharm. 2018;12(01):S31–S41.

Hauser H. Phospholipid vesicles. In: Cevc G, (ed). Phospholipids handbook. Boca Raton: CRC Press; 1993: 603–637.

Parajapati SK, Maurya SD, Das MK, Tilak VK, Verma KK, Dhakar RC. Potential application of dendrimers in drug delivery: A concise review and update. J Drug Deliv Ther. 2016;6(2):71–88. https://doi.org/10.22270/jddt.v6i2.1195

Wang H, Huang Q, Chang H, Xiao J, Cheng Y. Stimuli-responsive dendrimers in drug delivery. Biomater Sci. 2016;4(3):375–390. https://doi.org/10.1039/C5BM00532A

Huang D, Wu D. Biodegradable dendrimers for drug delivery. Mater Sci Eng C. 2018;90:713–727. https://doi.org/10.1016/j.msec.2018.03.002

Taheri-Kafrani A, Shirzadfar H, Tavassoli-Kafrani E. Dendrimers and dendrimers-grafted superparamagnetic iron oxide nanoparticles: Synthesis, characterization, functionalization, and biological applications in drug delivery systems. In: Grumezescu AM, (ed). Nano-and Microscale Drug Delivery Systems. Elsevier; 2017: 75–94. https://doi.org/10.1016/B978-0-323-52727-9.00005-4

Buitrago MdlSE, Fernández MÁM. Dendrimers and their applications in biomedicine: Dendrimer-drug interaction, a new therapeutic alternative. In: Kesharwani P, ed. Dendrimer-Based Nanotherapeutics. Academic Press; 2021:163–182. https://doi.org/10.1016/B978-0-12-821250-9.00019-6

Bhatia S. Nanoparticles types, classification, characterization, fabrication methods and drug delivery applications. In: Bhatia S, ed. Natural Polymer Drug Delivery Systems: Nanoparticles, Plants, and Algae. Springer Cham; 2016: 33–93. https://doi.org/10.1007/978-3-319-41129-3_2

Bhakya S, Muthukrishnan S, Sukumaran M, Muthukumar M. Biogenic synthesis of silver nanoparticles and their antioxidant and antibacterial activity. Appl Nanosci. 2016;6:755–766. https://doi.org/10.1007/s13204-015-0473-z

Rudramurthy GR, Swamy MK. Potential applications of engineered nanoparticles in medicine and biology: An update. J Biol Inorg Chem. 2018;23:1185–1204. https://doi.org/10.1007/s00775-018-1600-6

McNamara K, Tofail SA. Nanoparticles in biomedical applications. Adv Phys-X. 2017;2(1):54–88. https://doi.org/10.1080/23746149.2016.1254570

Nuruzzaman M, Rahman MM, Liu Y, Naidu R. Nanoencapsulation, nano-guard for pesticides: A new window for safe application. J Agric Food Chem. 2016;64(7):1447–1483. https://doi.org/10.1021/acs.jafc.5b05214

Patel J, Patel A, Patel N. Nanotechnology in TB diagnosis. In: Shegokar R, Pathak Y, (eds). Infectious Diseases Drug Delivery Systems. Springer; 2023: 101–125.

Yigit MV, Moore A, Medarova Z. Magnetic nanoparticles for cancer diagnosis and therapy. Pharm Res. 2012;29:1180–1188. https://doi.org/10.1007/s11095-012-0679-7

Wu M, Huang S. Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment. Mol Clin Oncol. 2017;7(5):738–746. https://doi.org/10.3892/mco.2017.1399

Seleci D, Seleci M, Walter J, Stahl F, Scheper T. Niosomes as nanoparticular drug carriers: Fundamentals and recent applications. J Nanomater. 2016;2016:e7372306. https://doi.org/10.1155/2016/7372306

Revia RA, Zhang M. Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: Recent advances. Mater Today. 2016;19(3):157–168. https://doi.org/10.1016/j.mattod.2015.08.022

Arap W, Pasqualini R, Montalti M, et al. Luminescent silica nanoparticles for cancer diagnosis. Curr Med Chem. 2013;20(17):2195–2211.

Manescu V, Paltanea G, Antoniac I, Vasilescu M. Magnetic nanoparticles used in oncology. Materials. 2021;14(20):e5948. https://doi.org/10.3390/ma14205948

Hersh AM, Alomari S, Tyler BM. Crossing the blood-brain barrier: Advances in nanoparticle technology for drug delivery in neuro-oncology. Int J Mol Sci. 2022;23(8):e4153. https://doi.org/10.3390/ijms23084153

Bejarano J, Navarro-Marquez M, Morales-Zavala F, et al. Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches. Theranostics. 2018;8(17):4710–4732. https://doi.org/10.7150%2Fthno.26284

Mieszawska AJ, Mulder WJ, Fayad ZA, Cormode DP. Multifunctional gold nanoparticles for diagnosis and therapy of disease. Mol Pharmaceutics. 2013;10(3):831–847. https://doi.org/10.1021/mp3005885

Carneiro MFH, Barbosa F Jr.. Gold nanoparticles: A critical review of therapeutic applications and toxicological aspects. J Toxicol Environ Health B. 2016;19(3-4):129–148. https://doi.org/10.1080/10937404.2016.1168762

Sercan D, Altay F. Biosensors from the first generation to nano-biosensors. Int Adv Res Eng J. 2018;2(2):200–207.

Soler M, Huertas CS, Lechuga LM. Label-free plasmonic biosensors for point-of-care diagnostics: A review. Expert Rev Mol Diagn. 2019;19(1):71–81. https://doi.org/10.1080/14737159.2019.1554435

Mauriz E, Dey P, Lechuga LM. Advances in nano plasmonic biosensors for clinical applications. Analyst. 2019;144(24):7105–7129. https://doi.org/10.1039/C9AN00701F

He J, Li C, Ding L, et al. Tumor targeting strategies of smart fluorescent nanoparticles and their applications in cancer diagnosis and treatment. Adv Mater. 2019;31(40):e1902409. https://doi.org/10.1002/adma.201902409

Yuan P, Ding X, Yang YY, Xu QH. Metal nanoparticles for diagnosis and therapy of bacterial infection. Adv Healthc Mater. 2018;7(13):e1701392. https://doi.org/10.1002/adhm.201701392

Fernando S, Gunasekara T, Holton J. Antimicrobial nanoparticles: Applications and mechanisms of action. Sri Lankan J Infect Dis. 2018;8(1):2–11. http://dx.doi.org/10.4038/sljid.v8i1.8167

Kumar VV, Anthony SP. Antimicrobial studies of metal and metal oxide nanoparticles. In: Grumezescu AM, (ed). Surface Chemistry of Nanobiomaterials. Elsevier; 2016: 265–300.

Slavin YN, Asnis J, Hńfeli UO, Bach H. Metal nanoparticles: Understanding the mechanisms behind antibacterial activity. J Nanobiotechnol. 2017;15:e65. https://doi.org/10.1186/s12951-017-0308-z

Salomoni R, Léo P, Montemor A, Rinaldi B, Rodrigues M. Antibacterial effect of silver nanoparticles in Pseudomonas aeruginosa. Nanotechnol Sci Appl. 2017;10:115–121. https://doi.org/10.2147/NSA.S133415

Scioli Montoto S, Muraca G, Ruiz ME. Solid lipid nanoparticles for drug delivery: Pharmacological and biopharmaceutical aspects. Front Mol Biosci. 2020;7:e587997. https://doi.org/10.3389/fmolb.2020.587997

Almawash S. Solid lipid nanoparticles, an effective carrier for classical antifungal drugs. Saudi Pharm J. 2023;31(7):1167–1180. https://doi.org/10.1016/j.jsps.2023.05.011

Tsai T-T, Huang C-Y, Chen C-A, et al. Diagnosis of Tuberculosis using colorimetric gold nanoparticles on a paper-based analytical device. ACS Sens. 2017;2(9):1345–1354. https://doi.org/10.1021/acssensors.7b00450

Tsai T-T, Shen S-W, Cheng C-M, Chen C-F. Paper-based tuberculosis diagnostic devices with colorimetric gold nanoparticles. Sci Technol Adv Mater. 2013;14(4):e044404. https://doi.org/10.1088/1468-6996/14/4/044404

Tufa LT, Oh S, Tran VT, et al. Electrochemical immunosensor using nanotriplex of graphene quantum dots, Fe3O4, and Ag nanoparticles for Tuberculosis. Electrochim Acta. 2018;290:369–377. https://doi.org/10.1016/j.electacta.2018.09.108

León-Janampa N, Zimic M, Shinkaruk S, et al. Synthesis, characterization and bio-functionalization of magnetic nanoparticles to improve the diagnosis of tuberculosis. Nanotechnol. 2020;31(17):e175101. https://doi.org/10.1088/1361-6528/ab6ab1

Bhusal N, Shrestha S, Pote N, Alocilja EC. Nanoparticle-based biosensing of tuberculosis, an affordable and practical alternative to current methods. Biosensors. 2019;9(1):e1. https://doi.org/10.3390/bios9010001

Yang Y. Upconversion nanophosphors for use in bioimaging, therapy, drug delivery and bioassays. Microchim Acta. 2014;181:263–294. https://doi.org/10.1007/s00604-013-1139-8

Yarbakht M, Nikkhah M. Unmodified gold nanoparticles as a colorimetric probe for visual methamphetamine detection. J Exp Nanosci. 2016;11(7):593–601. https://doi.org/10.1080/17458080.2015.1100333

Wu K, Chugh VK, D. Krishna V, et al. One-step, wash-free, nanoparticle clustering-based magnetic particle spectroscopy bioassay method for detection of SARS-CoV-2 spike and nucleocapsid proteins in the liquid phase. ACS Appl Mater Interfaces. 2021;13(37):44136–44146. https://doi.org/10.1021/acsami.1c14657

Wolfbeis OS. An overview of nanoparticles commonly used in fluorescent bioimaging. Chem Soc Rev. 2015;44:4743–4768. https://doi.org/10.1039/C4CS00392F

DaCosta MV, Doughan S, Han Y, Krull UJ. Lanthanide upconversion nanoparticles and applications in bioassays and bioimaging: A review. Anal Chim Acta. 2014;832:1–33. https://doi.org/10.1016/j.aca.2014.04.030

Baetke SC, Lammers T, Kiessling F. Applications of nanoparticles for diagnosis and therapy of cancer. Br J Radiol. 2015;88(1054):e20150207. https://doi.org/10.1259/bjr.20150207

Naahidi S, Jafari M, Edalat F, Raymond K, Khademhosseini A, Chen P. Biocompatibility of engineered nanoparticles for drug delivery. J Control Release. 2013;166(2):182–194. https://doi.org/10.1016/j.jconrel.2012.12.013

Cheng CJ, Tietjen GT, Saucier-Sawyer JK, Saltzman WM. A holistic approach to targeting disease with polymeric nanoparticles. Nat Rev Drug Discov. 2015;14:239–247. https://doi.org/10.1038/nrd4503

Stockwell J, Abdi N, Lu X, Maheshwari O, Taghibiglou C. Novel central nervous system drug delivery systems. Chem Biol Drug Des. 2014;83(5):507–520. https://doi.org/10.1111/cbdd.12268

Zhu Y, Liao L. Applications of nanoparticles for anticancer drug delivery: A review. J Nanosci Nanotechnol. 2015;15(7):4753–4773. https://doi.org/10.1166/jnn.2015.10298

Sender R, Milo R. The distribution of cellular turnover in the human body. Nat Med. 2021;27:45–48. https://doi.org/10.1038/s41591-020-01182-9

Kang C, Sun Y, Zhu J, et al. Delivery of nanoparticles for treatment of brain tumor. Curr Drug Metab. 2016;17(8):745–754.

Zhang C, Zheng X, Wan X, et al. The potential use of H102 peptide-loaded dual-functional nanoparticles in the treatment of Alzheimer's disease. J Control Release. 2014;192:317–324. https://doi.org/10.1016/j.jconrel.2014.07.050

Abbas M. Potential role of nanoparticles in treating the accumulation of amyloid-beta peptide in Alzheimer’s patients. Polymers. 2021;13(7):e1051. https://doi.org/10.3390/polym13071051

Hartl N, Adams F, Merkel OM. From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood–brain barrier. Adv Ther. 2021;4(1):e2000092. https://doi.org/10.1002/adtp.202000092

Loureiro JA, Andrade S, Duarte A, et al. Resveratrol and grape extract-loaded solid lipid nanoparticles for the treatment of Alzheimer’s disease. Molecules. 2017;22(2):e277. https://doi.org/10.3390/molecules22020277

Casals E, Zeng M, Parra‐Robert M, et al. Cerium oxide nanoparticles: Advances in biodistribution, toxicity, and preclinical exploration. Small. 2020;16(20):e1907322. https://doi.org/10.1002/smll.201907322

Published
2023-06-28
How to Cite
Naeem, Z., Rana, T., & Javaid, S. (2023). Evaluating Frontiers in Nanotechnology: A Review of Novel Nanoparticle Technology in Drug Delivery Systems (DDS). Currents in Pharmaceutical Research, 1(1), 16-46. https://doi.org/10.32350/cpr.11.03
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Articles