Prevalence of Common Haematological Abnormalities Identified in Routine CBC Reports from a Local Pathology Laboratory in Mandi Bahauddin, Pakistan

Keywords: complete blood count (CBC), haematological abnormalities, iron deficiency anemia, Pakistan, pancytopenia, prevalence

Abstract

Abstract Views: 0

The Complete Blood Count (CBC) is an affordable and widely accessible test that plays a crucial role in identifying a variety of blood-related disorders. Understanding how often these abnormalities are observed and how they differ across demographic groups would help shape effective and focused public health strategies. The current research used standard CBC test results from a local laboratory in Mandi Bahauddin (Punjab, Pakistan) to examine the laboratory variations among different demographic groups and assessed the frequency of particular blood disorders. In this cross-sectional retrospective study, 1017 CBC reports of patients of various ages and both genders were received. The blood abnormalities were defined with standard diagnosis criteria, and their occurrence rates were analyzed. The information was also stratified by age (0-20, 41-60 and 21-40 years) and gender. The description statistics were applied to the analysis. Over half (55.5%) of the reports showed at least one abnormality and 44.5% were normal. Iron deficiency was the most frequent diagnosis, followed by normocytic anemia (7.3%) and leucocytosis (8.5%). It was observed that more women were affected by Iron Deficiency Anemia (IDA) (79.5%) and megaloblastic anemia (82.4%) as compared to men. It is highly common in young adults (68.0%) between the age of 21–40 years, IDA was more prevalent than other population groups. Pancytopenia was found to be rare (1.5%) and occurred in all age groups. Iron deficiency was the leading haematological abnormality in the study subjects, especially in women of child bearing age. Even with the CBC test, early assessment is still possible. To reduce the impact of anemia and other blood disorders on the community, it is necessary to implement focused nutritional programs and public-health initiatives.

Downloads

Download data is not yet available.

References

May JE, Marques MB, Reddy VV, Gangaraju R. Three neglected numbers in the CBC: the RDW, MPV, and NRBC count. Cleve Clin J Med. 2019;86(3):167-72. https://doi.org/10.3949/ccjm.86a.18072

Agnello L, Giglio RV, Bivona G, et al. The value of a complete blood count (CBC) for sepsis diagnosis and prognosis. Diagnostics. 2021;11(10):e1881. https://doi.org/10.3390/diagnostics11101881

Seo IH, Lee YJ. Usefulness of complete blood count (CBC) to assess cardiovascular and metabolic diseases in clinical settings: a comprehensive literature review. Biomedicines. 2022;10(11):e2697. https://doi.org/10.3390/biomedicines10112697

Sheshunova R. Prevalence of blood diseases among adult population and organization of hematological care. Aspirantskiy Vestnik Povolzhiya, 2017;17(1-2):204-209. https://doi.org/10.17816/2072-2354.2017.0.1-2.204-209

Palmblad J, Siersma V, Lind B, Bjerrum OW, Hasselbalch H, Andersen CL. Age‐related prevalence and clinical significance of neutropenia‐isolated or combined with other cytopenias: real-world data from 373 820 primary care individuals. Am J Haematol. 2020;95(5):521-528. https://doi.org/10.1002/ajh.25756

Muntaha ST, Ayaz H, Mahmood H, Kulsoom A, Tayyab M, Farooq A. The frequency of hematological abnormalities in children (Age 1 Month To 12 Years) Presenting with Sars-CoV-2 infection At Shifa International Hospital. J Rawalpindi Med College. 2024;28(1):440-446. https://doi.org/10.37939/jrmc.v28i1.2424

Pathak B, Maimoon S. A cross-sectional study of hematological parameters in the geriatric population using peripheral smear examination and a five-part cell counter. Cureus. 2024;16(4):e57910. https://doi.org/10.7759/cureus.57910

Vieth JT, Lane DR. Anemia. Emerg Med Clinic. 2014;32(3):613-628. https://doi.org/10.1016/j.emc.2014.04.007

Cappellini MD, Motta I. Anemia in clinical practice—definition and classification: does hemoglobin change with aging? Semin Hematol. 2015;52(4);261-269. https://doi.org/10.1053/j.seminhematol.2015.07.006

Riley LK, Rupert J. Evaluation of patients with leukocytosis. Am Family Phy. 2015;92(11):1004-1011.

Lee EJ, Lee AI. Thrombocytopenia. Prim Care Clin Office Pract. 2016;43(4):543-557. https://doi.org/10.1016/j.pop.2016.07.008

Smock KJ, Perkins SL. Thrombocytopenia: an update. Int J Laborat Hematol. 2014;36(3):269-278. https://doi.org/10.1111/ijlh.12214

Venkatasai JP, Srinivasamaharaj S, Sneha LM, Scott JX, Baby AK, Rajan M. Pediatric hematological malignancy: identification of issues involved in the road to diagnosis. South Asian J Cancer. 2017;6(01):28-30. https://doi.org/10.4103/2278-330X.202559

Gohad G, Palaskar PG. How to detect multiple myeloma early and get treatment. In: Oruganti SK, Karras D, Thakur SS, Nagpal K, Gupta SK, eds. Case Studies on Holistic Medical Interventions. CRC Press; 2025:597-599. https://doi.org/10.1201/9781003596684

Khadayate R, Sahu P, Sahu S, Karale S. Study of hematological profile in chronic renal failure patients on hemodialysis in a tertiary care hospital. Int J Heal Sci Res. 2020;10(12):1-7.

Saad S, Ali RP, Najam U, Shahid U, Mirza AJ. Early CBC screening for detecting subclinical anemia in adolescent females. Pak J Med Dent. 2025;14(1):152-156. https://doi.org/10.36283/ziun-pjmd14-1/022

Suresh M, Khadkikar K, Daware S, Salvi S. Analysing blood abnormalities using complete blood count data: a statistical approach. Int J Chem Biochem Sci. 2023;24(12):838-844.

Hussein RM. Hematological assessment through randomized cbc testing in Erbil, Kurdistan region of Iraq. Paper presented at: International Scientific Research Congress; March 7-9, 2025; Antalya, Türkiye.

Habib MA, Raynes-Greenow C, Soofi SB, et al. Prevalence and determinants of iron deficiency anemia among non-pregnant women of reproductive age in Pakistan. Asia Pac J Clin Nutr. 2018;27(1):195-203. https://doi.org/10.6133/apjcn.042017.14

Abramson N, Melton B. Leukocytosis: basics of clinical assessment. Am Fam Phy. 2000;62(9):2053-2060.

Brill JR, Baumgardner DJ. Normocytic anemia. Am Fam Physician. 2000;62(10):2255-2263.

Santra G, Das BK. A cross-sectional study of the clinical profile and aetiological spectrum of pancytopenia in a tertiary care centre. Singapore Med J. 2010;51(10):e806.

Furlong E, Carter T. Aplastic anemia: current concepts in diagnosis and management. J Paediat Child Health. 2020;56(7):1023-1028.

Published
2025-12-17
How to Cite
Riaz, A., Sajid, A., Fatima, Z., Nadeem, A., Mehwish, Mansoor, M., & Rehman, P. (2025). Prevalence of Common Haematological Abnormalities Identified in Routine CBC Reports from a Local Pathology Laboratory in Mandi Bahauddin, Pakistan. International Health Review , 5(2), 45-61. https://doi.org/10.32350/ihr.52.03
Section
Original Article