Antimicrobial Susceptibility Patterns of Pseudomonas Aeruginosa Isolates in A Tertiary Care Hospital, Peshawar, Pakistan
DOI:
https://doi.org/10.32350/bsr.63.09Keywords:
beta-lactamases, efflux pumps, Pseudomonas aeruginosaAbstract
Background. Pseudomonas aeruginosa is an opportunistic pathogen that takes advantage of the host’s weakened system and causes many life-threatening, persistent infections including cystic fibrosis and other lung infections that account for high mortality rates. The presence of several resistant genes (multiple MDR efflux pumps, beta-lactamases) in the genome of P. aeruginosa makes it resistant to many available antibiotics, thus making the currently used treatment options ineffective.
Method. The current study was cross-sectional and focused on examining patients with reported Pseudomonas infections and the analysis of their antibiotic susceptibility profile. Convenient random sampling technique was used.
Results. A total of 101 male and 74 female patients were analyzed and admitted at Rehman Medical Institute. Among them, patients in the age group 41-60 years were the most affected. Antibiotic sensitivity testing reported colistin sulphate as a highly sensitive drug since all the isolates were sensitive to it, followed by imipenem and amikacin.
Conclusion. It was concluded that the most effective antibiotics reported against pseudomonal infections were colistin sulphate and imipenem, whereas aminoglycosides yielded variable outcomes.
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